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Morphinans

Known as: Morphinans [Chemical/Ingredient], morphinan 
Compounds based on a partially saturated iminoethanophenanthrene, which can be described as ethylimino-bridged benzo-decahydronaphthalenes. They… Expand
National Institutes of Health

Papers overview

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Highly Cited
2018
Highly Cited
2018
Poppy genome reveals evolution of opiates The opium poppy has been a source of painkillers since Neolithic times. Attendant risks… Expand
Highly Cited
2015
Highly Cited
2015
Activation of the μ-opioid receptor (μOR) is responsible for the efficacy of the most effective analgesics. To shed light on the… Expand
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Highly Cited
2015
Highly Cited
2015
Substrate channeling in morphine biosynthesis Poppies are still the most economically viable source of the excellent painkiller… Expand
Highly Cited
2015
Highly Cited
2015
Morphinan alkaloids are the most powerful narcotic analgesics currently used to treat moderate to severe and chronic pain. The… Expand
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Highly Cited
2012
Highly Cited
2012
Opium is one of the world’s oldest drugs, and its derivatives morphine and codeine are among the most used clinical drugs to… Expand
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Highly Cited
2012
Highly Cited
2012
Opioid receptors mediate the actions of endogenous and exogenous opioids on many physiological processes, including the… Expand
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Review
2010
Review
2010
Parkinson’s disease (PD) is a neurodegenerative movement disorder characterized by the progressive loss of dopaminergic neurons… Expand
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Highly Cited
2008
Highly Cited
2008
The benzylisoquinoline alkaloids (BIAs) are a diverse class of metabolites that exhibit a broad range of pharmacological… Expand
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Highly Cited
1998
Highly Cited
1998
Cytochromes mediating the biotransformation of dextromethorphan to dextrorphan and 3‐methoxymorphinan, its principal metabolites… Expand
Highly Cited
1998
Highly Cited
1998
UGT2B7 has been cloned and expressed previously in COS cells and HK293 cells. Two forms have been identified: one with a tyrosine… Expand