Semantic Scholar uses AI to extract papers important to this topic.
Poppy genome reveals evolution of opiates The opium poppy has been a source of painkillers since Neolithic times. Attendant risks… Expand Activation of the μ-opioid receptor (μOR) is responsible for the efficacy of the most effective analgesics. To shed light on the… Expand Substrate channeling in morphine biosynthesis Poppies are still the most economically viable source of the excellent painkiller… Expand Morphinan alkaloids are the most powerful narcotic analgesics currently used to treat moderate to severe and chronic pain. The… Expand Opium is one of the world’s oldest drugs, and its derivatives morphine and codeine are among the most used clinical drugs to… Expand Opioid receptors mediate the actions of endogenous and exogenous opioids on many physiological processes, including the… Expand Parkinson’s disease (PD) is a neurodegenerative movement disorder characterized by the progressive loss of dopaminergic neurons… Expand The benzylisoquinoline alkaloids (BIAs) are a diverse class of metabolites that exhibit a broad range of pharmacological… Expand Cytochromes mediating the biotransformation of dextromethorphan to dextrorphan and 3‐methoxymorphinan, its principal metabolites… Expand UGT2B7 has been cloned and expressed previously in COS cells and HK293 cells. Two forms have been identified: one with a tyrosine… Expand