Memory--a century of consolidation.
- J. D. McGaugh
- Biology, PsychologyScience
- 14 January 2000
This review examines the progress made over the century in understanding the time-dependent processes that create the authors' lasting memories.
The amygdala modulates the consolidation of memories of emotionally arousing experiences.
- J. D. McGaugh
- Biology, PsychologyAnnual Review of Neuroscience
- 24 June 2004
Findings from animal and human studies indicate that the amygdala mediates the memory-modulating effects of adrenal stress hormones and several classes of neurotransmitters and plays a key role in enabling emotionally significant experiences to be well remembered.
Inactivation of Hippocampus or Caudate Nucleus with Lidocaine Differentially Affects Expression of Place and Response Learning
The findings indicate: (1) the hippocampus and caudate nucleus selectively mediate expression of place and response learning, respectively, and in a visually cued extramaze environment, hippocampal-dependent place learning is acquired faster than caUDate-dependent response learning.
Inhibition of Activity-Dependent Arc Protein Expression in the Rat Hippocampus Impairs the Maintenance of Long-Term Potentiation and the Consolidation of Long-Term Memory
Investigation of the role of the IEGArc in hippocampal plasticity shows that disruption of Arc protein expression impairs the maintenance phase of LTP without affecting its induction and impairs consolidation of LTM for spatial water task training without affecting task acquisition or short-term memory.
Mechanisms of emotional arousal and lasting declarative memory
Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice
Amygdala activity at encoding correlated with long-term, free recall of emotional information.
- L. Cahill, R. Haier, J. D. McGaugh
- PsychologyProceedings of the National Academy of Sciences…
- 23 July 1996
The findings support the view derived from both animal and human investigations that the AC is selectively involved with the formation of enhanced long-term memory associated with emotionally arousing events.
Experience-Dependent Gene Expression in the Rat Hippocampus after Spatial Learning: A Comparison of the Immediate-Early GenesArc, c-fos, and zif268
- J. Guzowski, B. Setlow, E. Wagner, J. D. McGaugh
- Biology, PsychologyJournal of Neuroscience
- 15 July 2001
Although the expression of Arc, zif268, and c-fos exhibited many similarities, Arc was most responsive to differences in behavioral task demands, and IEG RNA levels were positively correlated within a structure.
Time-Dependent Processes in Memory Storage
- J. D. McGaugh
- Psychology, BiologyScience
- 16 September 1966
The findings indicate that the long-lasting trace of an experience is not completely fixed, consolidated, or coded at the time of the experience, and that any search for the engram or the basis of memory is not going to be successful.
Glucocorticoid enhancement of memory requires arousal-induced noradrenergic activation in the basolateral amygdala.
- B. Roozendaal, S. Okuda, E. A. van der Zee, J. D. McGaugh
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 25 April 2006
The findings strongly suggest that synergistic actions of glucocorticoids and emotional arousal-induced noradrenergic activation of the basolateral complex of the amygdala (BLA) constitute a neural mechanism by which glucoc Corticoidoids may selectively enhance memory consolidation for emotionally arousing experiences.