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Memory--a century of consolidation.
This review examines the progress made over the century in understanding the time-dependent processes that create the authors' lasting memories. Expand
The amygdala modulates the consolidation of memories of emotionally arousing experiences.
  • J. D. McGaugh
  • Psychology, Medicine
  • Annual review of neuroscience
  • 24 June 2004
Findings from animal and human studies indicate that the amygdala mediates the memory-modulating effects of adrenal stress hormones and several classes of neurotransmitters and plays a key role in enabling emotionally significant experiences to be well remembered. Expand
Inactivation of Hippocampus or Caudate Nucleus with Lidocaine Differentially Affects Expression of Place and Response Learning
The findings indicate: (1) the hippocampus and caudate nucleus selectively mediate expression of place and response learning, respectively, and in a visually cued extramaze environment, hippocampal-dependent place learning is acquired faster than caUDate-dependent response learning. Expand
Inhibition of Activity-Dependent Arc Protein Expression in the Rat Hippocampus Impairs the Maintenance of Long-Term Potentiation and the Consolidation of Long-Term Memory
Investigation of the role of the IEGArc in hippocampal plasticity shows that disruption of Arc protein expression impairs the maintenance phase of LTP without affecting its induction and impairs consolidation of LTM for spatial water task training without affecting task acquisition or short-term memory. Expand
Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice
This study strongly implicates intraneuronal Abeta in the onset of cognitive dysfunction in the 3xTg-AD mice, and rescues the early cognitive deficits on a hippocampal-dependent task. Expand
Amygdala activity at encoding correlated with long-term, free recall of emotional information.
The findings support the view derived from both animal and human investigations that the AC is selectively involved with the formation of enhanced long-term memory associated with emotionally arousing events. Expand
Mechanisms of emotional arousal and lasting declarative memory
Human-subject studies confirm the prediction of animal work that the amygdala is involved with the formation of enhanced declarative memory for emotionally arousing events and suggest that the amygdaloid complex serves to influence memory-storage processes in other brain regions. Expand
Experience-Dependent Gene Expression in the Rat Hippocampus after Spatial Learning: A Comparison of the Immediate-Early GenesArc, c-fos, and zif268
Although the expression of Arc, zif268, and c-fos exhibited many similarities, Arc was most responsive to differences in behavioral task demands, and IEG RNA levels were positively correlated within a structure. Expand
Glucocorticoids Increase Amyloid-β and Tau Pathology in a Mouse Model of Alzheimer’s Disease
It is reported that stress-level glucocorticoid administration increases Aβ formation by increasing steady-state levels of amyloid precursor protein (APP) and β-APP cleaving enzyme and augments tau accumulation, indicating that this hormone also accelerates the development of neurofibrillary tangles. Expand
Stress and glucocorticoids impair retrieval of long-term spatial memory
It is shown that rats have impaired performance in a water-maze spatial task after being given footshock 30 min before retention testing but are not impaired when footshock is given 2’min or 4 h before testing, which suggests that the retention impairment is directly related to increased adrenocortical function. Expand