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KLLN gene

Known as: KLLN, KILLIN, killin, p53-regulated DNA replication inhibitor 
This gene is involved in both DNA binding and apoptosis regulation.
National Institutes of Health

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Related topics

4 relations
ApoptosisCell Cycle Controldna binding

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KLLN wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
LINC00472 Acts as a Tumor Suppressor in NSCLC through KLLN-Mediated p53-Signaling Pathway via MicroRNA-149-3p and MicroRNA-4270
2019
2019
MiR‐744‐3p regulates keratinocyte proliferation and differentiation via targeting KLLN in psoriasis
Psoriasis is a chronic inflammatory disease, and microRNAs have been reported to regulate the pathogenesis of psoriasis. Up… 
2019
2019
A multi-gene panel beyond BRCA1/BRCA2 to identify new breast cancer-predisposing mutations by a picodroplet PCR followed by a next-generation sequencing strategy: a pilot study.
Review
2015
Review
2015
Role of DNA methylation in renal cell carcinoma
Alterations in DNA methylation are seen in cancers and have also been examined in clear cell renal cell carcinoma (ccRCC… 
Highly Cited
2015
Highly Cited
2015
Germline PTEN, SDHB‐D, and KLLN alterations in endometrial cancer patients with Cowden and Cowden‐like syndromes: An international, multicenter, prospective study
Endometrial cancer has been recognized only recently as a major component of Cowden syndrome (CS). Germline alterations in… 
2015
2015
KLLN epigenotype–phenotype associations in Cowden syndrome
Germline KLLN promoter hypermethylation was recently identified as a potential genetic etiology of the cancer predisposition… 
2013
2013
Activation of AR Sensitizes Breast Carcinomas to NVP-BEZ235's Therapeutic Effect Mediated by PTEN and KLLN Upregulation
NVP-BEZ235 is a newly developed dual PI3K/mTOR inhibitor, being tested in multiple clinical trials, including breast cancer. NVP… 
Review
2011
Review
2011
S-phase-coupled apoptosis in tumor suppression
DNA replication is essential for accurate transmission of genomic information from parental to daughter cells. DNA replication is… 
Highly Cited
2008
Highly Cited
2008
Killin is a p53-regulated nuclear inhibitor of DNA synthesis
Cell growth arrest and apoptosis are two best-known biological functions of tumor-suppressor p53. However, genetic evidence… 
Highly Cited
2002
Highly Cited
2002
Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability
cDNA microarray hybridization was used in an attempt to identify novel genes participating in cellular responses to prolonged… 
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