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Oculo-auriculo-vertebral spectrum: clinical and molecular analysis of 51 patients.
- A. Beleza-Meireles, R. Hart, M. Tassabehji
- MedicineEuropean Journal of Medical Genetics
- 1 September 2015
Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of urine.
- J. Carrola, Cláudia M. Rocha, I. Duarte
- BiologyJournal of Proteome Research
- 7 January 2011
The results show the valuable potential of NMR-based metabonomics for finding putative biomarkers of lung cancer in urine, collected in a minimally invasive way, which may have important diagnostic impact, provided that these metabolites are found to be specifically disease-related.
Metabolic biomarkers of prenatal disorders: an exploratory NMR metabonomics study of second trimester maternal urine and blood plasma.
- Sílvia O. Diaz, J. Pinto, A. M. Gil
- BiologyJournal of Proteome Research
- 30 June 2011
Results show that NMR metabonomics of maternal biofluids enables the noninvasive detection of metabolic changes associated to prenatal disorders, thus unveiling potential disorder biomarkers.
Human plasma stability during handling and storage: impact on NMR metabolomics.
- J. Pinto, M. Domingues, A. M. Gil
- MedicineIn Analysis
- 3 February 2014
The comparison between heparin and EDTA anti-coagulant collection tubes, the former showed no interference of the polysaccharide, while conserving full spectral information, and the impact of long-term -80 °C storage was found almost negligible.
Metabolic profiling of human lung cancer tissue by 1H high resolution magic angle spinning (HRMAS) NMR spectroscopy.
- Cláudia M. Rocha, António S. Barros, I. Duarte
- Biology, ChemistryJournal of proteome research
- 2010
Paired samples of tumor and noninvolved adjacent tissues from 12 lung tumors have been directly analyzed by (1)H HRMAS NMR (500/600 MHz) enabling, for the first time to the authors' knowledge, the identification of over 50 compounds.
Impact of prenatal disorders on the metabolic profile of second trimester amniotic fluid: a nuclear magnetic resonance metabonomic study.
Fetal malformations were found to have the highest impact on AF metabolite composition, enabling statistical validation to be achieved by several multivariate analytical tools, and newly found changes suggest possible additional effects on protein and nucleotide sugar biosynthesis.
Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of blood plasma.
- Cláudia M. Rocha, J. Carrola, I. Duarte
- Biology, MedicineJournal of Proteome Research
- 5 August 2011
Results indicate that NMR-based metabonomics of blood plasma can be useful as a screening tool to identify suspicious cases for subsequent, more specific radiological tests, thus contributing to improved disease management.
(1)H NMR based metabonomics of human amniotic fluid for the metabolic characterization of fetus malformations.
NMR results suggest that changes in gycolysis and gluconeogenesis as well as kidney underdevelopment occur in the malformed fetuses studied here.
Analytical approaches toward successful human cell metabolome studies by NMR spectroscopy.
- I. Duarte, Joana Marques, A. M. Gil
- BiologyAnalytical chemistry
- 22 May 2009
Cell lysis has a significant effect on cell lipid composition, making handling reproducibility an important issue in lipid analysis, and HRMAS was shown to be preferable to solution-state NMR of suspensions or supernatant, giving enhanced information on lipids and comparable resolution for smaller metabolites.
Effects of resistance exercise on endothelial progenitor cell mobilization in women
- F. Ribeiro, I. Ribeiro, J. Oliveira
- MedicineScientific Reports
- 19 December 2017
A dose-response relationship was observed, with the highest exercise intensities promoting the highest increases in EPCs and angiogenic factors.
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