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- Publications
- Influence
Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of urine.
- J. Carrola, Cláudia M. Rocha, +8 authors I. Duarte
- Chemistry, Medicine
- Journal of proteome research
- 7 January 2011
In this study, ¹H NMR-based metabonomics has been applied, for the first time to our knowledge, to investigate lung cancer metabolic signatures in urine, aiming at assessing the diagnostic potential… Expand
Oculo-auriculo-vertebral spectrum: clinical and molecular analysis of 51 patients.
- A. Beleza-Meireles, Rachel Hart, +20 authors M. Tassabehji
- Medicine
- European journal of medical genetics
- 1 September 2015
INTRODUCTION
Oculo-auriculo-vertebral spectrum (OAVS OMIM 164210) is a craniofacial developmental disorder affecting the development of the structures derived from the 1st and the 2nd branchial… Expand
Metabolic biomarkers of prenatal disorders: an exploratory NMR metabonomics study of second trimester maternal urine and blood plasma.
- Sílvia O. Diaz, Joana Pinto, +8 authors A. Gil
- Chemistry, Medicine
- Journal of proteome research
- 30 June 2011
This work describes an exploratory NMR metabonomic study of second trimester maternal urine and plasma, in an attempt to characterize the metabolic changes underlying prenatal disorders and identify… Expand
Metabolic profiling of human lung cancer tissue by 1H high resolution magic angle spinning (HRMAS) NMR spectroscopy.
- Cláudia M. Rocha, António S. Barros, +10 authors I. Duarte
- Chemistry, Medicine
- Journal of proteome research
- 2010
This work aims at characterizing the metabolic profile of human lung cancer, to gain new insights into tumor metabolism and to identify possible biomarkers with potential diagnostic value in the… Expand
Impact of prenatal disorders on the metabolic profile of second trimester amniotic fluid: a nuclear magnetic resonance metabonomic study.
- G. Graça, I. Duarte, +7 authors A. Gil
- Chemistry, Medicine
- Journal of proteome research
- 11 October 2010
This paper describes a metabonomic study of prenatal disorders using nuclear magnetic resonance (NMR) spectroscopy of amniotic fluid (AF) collected in the second trimester of pregnancy, to search for… Expand
UPLC-MS metabolic profiling of second trimester amniotic fluid and maternal urine and comparison with NMR spectral profiling for the identification of pregnancy disorder biomarkers.
- G. Graça, B. Goodfellow, +10 authors A. Gil
- Biology, Medicine
- Molecular bioSystems
- 1 April 2012
We report on the first untargeted UPLC-MS study of 2nd trimester maternal urine and amniotic fluid (AF), to investigate the possible metabolic effects of fetal malformations (FM), gestational… Expand
Human plasma stability during handling and storage: impact on NMR metabolomics.
- Joana Pinto, M. Domingues, +4 authors A. Gil
- Chemistry, Medicine
- The Analyst
- 3 February 2014
This work contributes to fill in some existing gaps in the knowledge of human plasma degradability during handling and storage, a paramount issue in Nuclear Magnetic Resonance (NMR) metabolomics.… Expand
Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of blood plasma.
- Cláudia M. Rocha, J. Carrola, +8 authors I. Duarte
- Chemistry, Medicine
- Journal of proteome research
- 5 August 2011
In this work, the variations in the metabolic profile of blood plasma from lung cancer patients and healthy controls were investigated through NMR-based metabonomics, to assess the potential of this… Expand
Analytical approaches toward successful human cell metabolome studies by NMR spectroscopy.
- I. Duarte, Joana Marques, +8 authors A. Gil
- Chemistry, Medicine
- Analytical chemistry
- 22 May 2009
The aim of this work was to investigate the effects of cell handling and storage on cell integrity and (1)H high resolution magic angle spinning (HRMAS) NMR spectra. Three different cell types have… Expand
(1)H NMR based metabonomics of human amniotic fluid for the metabolic characterization of fetus malformations.
An NMR-metabonomic study of malformed fetuses was carried out through human amniotic fluid (HAF) analysis. Over 70 compounds were detected in control HAF by NMR. Possible confounding variables (fetus… Expand