KL gene

Known as: KLOTHO, Klotho Gene, ALPHA-KLOTHO 
This gene is involved in signaling.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to cardiovascular disease. Left… (More)
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Highly Cited
2007
Highly Cited
2007
Klotho, an antiaging gene with restricted organ distribution, is mainly expressed in the kidney tubules; the mutant mice have… (More)
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Highly Cited
2007
Highly Cited
2007
Familial tumoral calcinosis is characterized by ectopic calcifications and hyperphosphatemia due to inactivating mutations in… (More)
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Highly Cited
2006
Highly Cited
2006
The aging suppressor gene Klotho encodes a single-pass transmembrane protein. Klotho-deficient mice exhibit a variety of aging… (More)
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Highly Cited
2006
Highly Cited
2006
FGF23 is a unique member of the fibroblast growth factor (FGF) family because it acts as a hormone that derives from bone and… (More)
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Highly Cited
2005
Highly Cited
2005
A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that… (More)
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Highly Cited
2003
Highly Cited
2003
A new gene, termed klotho, is associated with the suppression of several aging phenotypes. Because high expression of klotho gene… (More)
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Highly Cited
1998
Highly Cited
1998
Inactivation of the klotho (kl) gene in mice results in multiple disorders that resemble human aging. The mouse kl gene encodes a… (More)
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Highly Cited
1998
Highly Cited
1998
We previously established a novel mouse model for human aging and identified the genetic foundation responsible for it. A defect… (More)
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Highly Cited
1997
Highly Cited
1997
A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in… (More)
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