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KL protein, human

Known as: EC 3.2.1.31, Klotho, klotho protein, human 
Klotho (1012 aa, ~116 kDa) is encoded by the human KL gene. This protein is involved in signal transduction.
National Institutes of Health

Related topics

Related topics

16 relations
AgingCarbohydrate MetabolismEnzyme GeneExtracellular Space

Broader (2)

KL wt Alleleklotho protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Klotho suppresses high phosphate-induced osteogenic responses in human aortic valve interstitial cells through inhibition of Sox9
Elevated level of blood phosphate (Pi) associated with chronic kidney disease (CKD) is a risk factor of aortic valve… 
2016
2016
Klotho modulates FGF23-mediated NO synthesis and oxidative stress in human coronary artery endothelial cells
Chronic kidney disease (CKD) is a state of Klotho deficiency and excess of the phosphaturic hormone fibroblast growth factor 23… 
Review
2015
Review
2015
α-Klotho's effects on mineral homeostasis are fibroblast growth factor-23 dependent
Purpose of review &agr;-Klotho (Klotho) occurs in three isoforms, a membrane-bound form acting as a coreceptor for fibroblast… 
2015
2015
The Effect of Klotho Treatment on Atherogenesis, Blood Pressure, and Metabolic Parameters in Experimental Rodent Models
Abstract Klotho is a transmembrane protein, expressed mainly in the kidneys and the choroid plexus. The extracellular domain of… 
2015
2015
[Retracted] Protective role of Klotho on cardiomyocytes upon hypoxia/reoxygenation via downregulation of Akt and FOXO1 phosphorylation. Mol Med Rep. 2015 Mar;11(3): 2013-9.
2014
2014
Cardiovascular disease: Role for Klotho and phosphate in cardiac remodelling
2014
2014
Upregulation of KCNQ1/KCNE1 K+ channels by Klotho
Klotho is a transmembrane protein expressed primarily in kidney, parathyroid gland, and choroid plexus. The extracellular domain… 
2013
2013
S51 Klotho is associated with skeletal muscle dysfunction and oxidative stress in COPD
Introduction Klotho is a transmembrane protein; klotho null mice develop sarcopenia and emphysema. We have previously found serum… 
Review
2009
Review
2009
Klotho gene, phosphocalcic metabolism, and survival in dialysis.
The discovery that two recently identified molecules, klotho and fibroblast growth factor 23 (FGF23), played an important role in… 
2004
2004
SIGNALING THROUGH THE AGING SUPPRESSOR FACTOR KLOTHO IN ENDOTHELIAL HOMEOSTASIS
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