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KL protein, human

Known as: EC 3.2.1.31, Klotho, klotho protein, human 
Klotho (1012 aa, ~116 kDa) is encoded by the human KL gene. This protein is involved in signal transduction.
National Institutes of Health

Related topics

Related topics

16 relations
AgingCarbohydrate MetabolismEnzyme GeneExtracellular Space

Broader (2)

KL wt Alleleklotho protein

Papers overview

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2018
2018
The Potential Role of Klotho as a Prognostic Biomarker in Deceased Donor Kidney Transplantation
Introductions Klotho, first known as an ‘aging suppressor’ factor, is produced in renal tubular epithelial cells and acts as co… 
2018
2018
[Effect of Ronghuang Granule on serum FGF23, FGFRs and Klotho in non-dialysis patients with CKD-MBD and kidney deficiency and damp-heat syndrome].
OBJECTIVE To observe the effect of Ronghuang granule on serum fibroblast growth factor 23 (FGF23), fibroblast growth factor… 
2018
2018
Klotho in vascular biology
Klotho is a protein named for the Greek goddess who spins the thread of life. This is a fitting name, as the Klotho protein has… 
2017
2017
Klotho suppresses high phosphate-induced osteogenic responses in human aortic valve interstitial cells through inhibition of Sox9
Elevated level of blood phosphate (Pi) associated with chronic kidney disease (CKD) is a risk factor of aortic valve… 
2017
2017
Roles of Klotho and Endothelin-1 in pseudoexfoliation
Serum and aqueous levels of Klotho levels are reduced in pseudoexfoliation syndrome (PXF) and pseudoexfoliative glaucoma (PEG… 
2016
2016
Klotho modulates FGF23-mediated NO synthesis and oxidative stress in human coronary artery endothelial cells
Chronic kidney disease (CKD) is a state of Klotho deficiency and excess of the phosphaturic hormone fibroblast growth factor 23… 
2016
2016
Assessment of plasma klotho concentration in stable COPD
Introduction: Klotho protein is associated with the mechanism of aging. In mice, a decrease in Kotho gene expression promotes… 
2015
2015
[Retracted] Protective role of Klotho on cardiomyocytes upon hypoxia/reoxygenation via downregulation of Akt and FOXO1 phosphorylation. Mol Med Rep. 2015 Mar;11(3): 2013-9.
2014
2014
Cardiovascular disease: Role for Klotho and phosphate in cardiac remodelling
2004
2004
HMG-CoA reductase inhibitors upregulate anti-aging klotho mRNA via RhoA inactivation in IMCD 3 cells
Objective: Klotho is thought to play a critical role in the development of age-related disorders including arteriosclerosis… 
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