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KL protein, human

Known as: EC 3.2.1.31, Klotho, klotho protein, human 
Klotho (1012 aa, ~116 kDa) is encoded by the human KL gene. This protein is involved in signal transduction.
National Institutes of Health

Related topics

Related topics

16 relations
AgingCarbohydrate MetabolismEnzyme GeneExtracellular Space

Broader (2)

KL wt Alleleklotho protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis
Mutations of the β-glucuronidase protein α-Klotho have been associated with premature aging, and altered cognitive function… 
Review
2018
Review
2018
Klotho protein in neurodegenerative disorders
The Klotho protein is a recently discovered protein and its overexpression is associated with life extension. Klotho deficiency… 
Highly Cited
2017
Highly Cited
2017
Klotho May Ameliorate Proteinuria by Targeting TRPC6 Channels in Podocytes.
Klotho is a type-1 membrane protein predominantly produced in the kidney, the extracellular domain of which is secreted into the… 
Highly Cited
2017
Highly Cited
2017
Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress
Mammalian members of the forkhead box protein O (FoxO) class of transcription factors are implicated in the regulation of… 
Review
2017
Review
2017
The role of the anti-ageing protein Klotho in vascular physiology and pathophysiology
Review
2015
Review
2015
Intracellular signaling of the aging suppressor protein Klotho.
The Klotho protein deficiency is known to participate in premature aging. As an aging suppressor, Klotho is an important molecule… 
2014
2014
Upregulation of the Creatine Transporter Slc6A8 by Klotho
Background/Aims: The transmembrane Klotho protein contributes to inhibition of 1,25(OH)2D3 formation. The extracellular domain of… 
Review
2014
Review
2014
Skeletal muscle as a regulator of the longevity protein, Klotho
Klotho is a powerful longevity protein that has been linked to the prevention of muscle atrophy, osteopenia, and cardiovascular… 
Highly Cited
2011
Highly Cited
2011
Downregulation of NaPi-IIa and NaPi-IIb Na+-coupled Phosphate Transporters by Coexpression of Klotho
Klotho, a transmembrane protein, protease and hormone has been shown to exert a profound effect on phosphate metabolism. Klotho… 
Highly Cited
2007
Highly Cited
2007
Anti-oxidative effect of Klotho on endothelial cells through cAMP activation
Klotho, a regulatory factor implicated in countering the aging process, has been reported to ameliorate endothelial dysfunction… 
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