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KISS1 wt Allele

Known as: KISS-1, KiSS-1 Metastasis-Suppressor wt Allele, MGC39258 
Human KISS1 wild-type allele is located in the vicinity of 1q32 and is approximately 6 kb in length. This allele, which encodes metastasis-suppressor… 
National Institutes of Health

Related topics

Related topics

6 relations
1q32Breast CarcinomaHomo sapiensMetastasis Suppression

Papers overview

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Highly Cited
2009
Highly Cited
2009
KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction.
Kisspeptins, the products of the KiSS-1 gene acting via G protein-coupled receptor 54 (GPR54), have recently emerged as pivotal… 
Highly Cited
2007
Highly Cited
2007
Direct Pituitary Effects of Kisspeptin: Activation of Gonadotrophs and Somatotrophs and Stimulation of Luteinising Hormone and Growth Hormone Secretion
Recent, compelling evidence indicates that kisspeptins, the products of KiSS‐1 gene, and their receptor GPR54, represent key… 
Highly Cited
2006
Highly Cited
2006
Administration of Kisspeptin‐54 into Discrete Regions of the Hypothalamus Potently Increases Plasma Luteinising Hormone and Testosterone in Male Adult Rats
Kisspeptin‐54 is the peptide product of the KiSS‐1 gene and an endogenous agonist of the GPR54 receptor. KiSS‐1 was initially… 
Highly Cited
2005
Highly Cited
2005
Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats.
Ovulation is caused by a sequence of neuroendocrine events: GnRH and LH surges that are induced by positive feedback action of… 
Highly Cited
2004
Highly Cited
2004
Advanced vaginal opening and precocious activation of the reproductive axis by KiSS‐1 peptide, the endogenous ligand of GPR54
The awakening of the gonadotrophic axis at puberty is the end‐point of a complex cascade of sex developmental events that leads… 
Highly Cited
2004
Highly Cited
2004
Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts
Trophoblast invasion of the uterine extracellular matrix, a critical process of human implantation and essential for fetal… 
Highly Cited
2004
Highly Cited
2004
Downregulation of KiSS‐1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma
KiSS‐1 is a promising candidate tumor‐suppressor gene and may play a key role in the metastatic cascade. The expression profile… 
Highly Cited
2003
Highly Cited
2003
Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases
A human placenta cDNA library was screened by the expression cloning method for gene products that interact with matrix… 
Highly Cited
2002
Highly Cited
2002
Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells.
The development of distant metastasis is the most important predictor of death from thyroid cancer. KiSS-1 is a recently cloned… 
Highly Cited
1997
Highly Cited
1997
Identification of highly expressed genes in metastasis‐suppressed chromosome 6/human malignant melanoma hybrid cells using subtractive hybridization and differential display
Microcell‐mediated transfer of chromosome 6 into human melanoma cell lines C8161 and MelJuSo suppresses metastasis by at least 95… 
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