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Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of…
The current data support the contention that the hypothalamic KiSS-1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
Sexual differentiation of Kiss1 gene expression in the brain of the rat.
The findings suggest that sex differences in kisspeptin signaling from the AVPV subserve the cellular mechanisms controlling the sexually differentiated GnRH/LH surge.
Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals
Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition.
The data are the first to show an interaction between energy status and the hypothalamic KiSS-1 system, which may constitute a target for disruption (and eventual therapeutic intervention) of pubertal development in conditions of negative energy balance.
Kisspeptins and reproduction: physiological roles and regulatory mechanisms.
- L. Pinilla, E. Aguilar, C. Diéguez, R. Millar, M. Tena-Sempere
- BiologyPhysiological reviews
- 1 July 2012
This review aims to provide a comprehensive account of the state-of-the-art in the field of kisspeptin physiology by covering in-depth the consensus knowledge on the major molecular features, biological effects, and mechanisms of action ofkisspeptins in mammals and, to a lesser extent, in nonmammalian vertebrates.
Advanced vaginal opening and precocious activation of the reproductive axis by KiSS‐1 peptide, the endogenous ligand of GPR54
- V. Navarro, R. Fernández-Fernández, M. Tena-Sempere
- Biology, MedicineThe Journal of physiology
- 1 December 2004
It is reported that chronic central administration of KiSS‐1 peptide to immature female rats induced the precocious activation of the gonadotrophic axis, as estimated by advanced vaginal opening, elevated uterus weight, and increased serum levels of luteinizing hormone (LH) and oestrogen.
Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism—pathogenesis, diagnosis and treatment
A timely diagnosis and treatment to induce puberty can be beneficial for sexual, bone and metabolic health, and might help minimize some the psychological effects of CHH.
Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line.
The present data further characterize the functional relevance and putative key mediators (such as leptin and NPY) of the metabolic regulation of the hypothalamic KiSS-1 system in the mouse.
Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat.
- V. Navarro, J. M. Castellano, R. Steiner
- BiologyAmerican journal of physiology. Endocrinology and…
Observations suggest that NKB/NK3R signaling in Kiss1/NKB/Dyn-producing neurons in the Arc has a pivotal role in the control of gonadotropin-releasing hormone (GnRH)/LH secretion and its regulation by E(2)-dependent negative feedback in the rat.
Intestinal Microbiota Is Influenced by Gender and Body Mass Index
The results suggest that gut microbiota may differ between men and women, and that these differences may be influenced by the grade of obesity, as a function of gender and changes in body mass index.