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Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer
Reconstitution of hsa-miR-342 in the colorectal cancer cell line HT-29 induced apoptosis, suggesting that this microRNA could function as a proapoptotic tumor suppressor and support a novel mechanism for silencing intronic microRNAs in cancer by epigenetic alterations of cognate host genes. Expand
Rapid sexing of preimplantation bovine embryo using consecutive and multiplex polymerase chain reaction (PCR) with biopsied single blastomere.
A rapid and reliable PCR method for the sexing of 8- to 16-cell stage bovine embryos using a single blastomere is developed, suggesting that trauma to the demi-embryo caused by single-blastomere aspiration using a bevelled micropipette was very small. Expand
Fibulin-3-mediated inhibition of epithelial-to-mesenchymal transition and self-renewal of ALDH+ lung cancer stem cells through IGF1R signaling
Overall, the results show that FBLN3 suppresses both EMT and self-renewal of the lung CSCs by modulating the IGF1R/PI3K/AKT/GSK3β pathway and that F BLN3 would be useful as an alternative CSC therapy. Expand
Elevation of adenylate energy charge by angiopoietin-like 4 enhances epithelial–mesenchymal transition by inducing 14-3-3γ expression
It is shown that EMT is an energy-demanding process fueled by glucose metabolism-derived adenosine triphosphate (ATP) and identified angiopoietin-like 4 (ANGPTL4) as a key player that coordinates an increase in cellular energy flux crucial for EMT via an ANGPTL 4/14-3-3γ signaling axis. Expand
Altered Hydroxylation of Estrogen in Patients with Postmenopausal Osteopenia
To study the possible contributions of the differences in estrogen metabolism to bone mass in postmenopausal osteopenia, spinal and femoral bone mineral densities (BMD) were measured, and 18 urinaryExpand
MUC4 regulates cellular senescence in head and neck squamous cell carcinoma through p16/Rb pathway
H Farghaly was omitted from the byline at final submission due to communication impediments outside the authors’ control during the manuscript review period which were shortly thereafter resolved. Expand
Involvement of c-Src kinase in the regulation of TGF-β1-induced apoptosis
It is hypothesized that activated c-Src in HCC may contribute to resistance against the apoptotic and/ or antiproliferative properties of TGF-β1. Expand
Opposite functions of HIF-α isoforms in VEGF induction by TGF-β1 under non-hypoxic conditions
It is suggested that autocrine TGF-β1 production may contribute to tumor angiogenesis via HIF-2α signaling under non-hypoxic conditions, providing a selective growth advantage for prostate tumor cells. Expand
The effect of odontoblast conditioned media and dentin non-collagenous proteins on the differentiation and mineralization of cementoblasts in vitro.
The results suggest that dentin matrix proteins, or the secreted products of odontoblasts, induced cementoblast differentiation and mineralization and may contribute to the development of a periodontal treatment that includes cementum regeneration. Expand
Trichostatin a improves preimplantation development of bovine cloned embryos and alters expression of epigenetic and pluripotency genes in cloned blastocysts.
It is suggested that TSA treatment after SCNT in bovine embryos can improve in vitro development of embryos by increasing the blastocysts formation and positive reprogramming of the reconstructed embryo genome caused by downregulation of DNA methylation and up-regulation of pluripotency. Expand