Skip to search formSkip to main contentSkip to account menu

KIRREL gene

Known as: nephrin-like protein 1, KIRREL, NEPH1 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm
The nephron is the basic structural and functional unit of the vertebrate kidney. It is composed of a glomerulus, the site of… 
Highly Cited
2008
Highly Cited
2008
Nephrin mutations can cause childhood-onset steroid-resistant nephrotic syndrome.
Classically, infants with mutations in NPHS1, which encodes nephrin, present with nephrotic syndrome within the first 3 mo of… 
Highly Cited
2008
Highly Cited
2008
Neph1, a Component of the Kidney Slit Diaphragm, Is Tyrosine-phosphorylated by the Src Family Tyrosine Kinase and Modulates Intracellular Signaling by Binding to Grb2*
There are several lines of evidence that the podocyte slit diaphragm (SD), which serves as a structural framework for the… 
Highly Cited
2007
Highly Cited
2007
Neph1 Cooperates with Nephrin To Transduce a Signal That Induces Actin Polymerization
ABSTRACT While the mechanisms that regulate actin dynamics in cellular motility are intensively studied, relatively little is… 
Highly Cited
2007
Highly Cited
2007
BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury.
In early diabetic renal injury, there is podocyte drop-out (but no decrease in the number of other glomerular cells) which is… 
Highly Cited
2006
Highly Cited
2006
Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin.
Focal segmental glomerulosclerosis (FSGS) is the most common primary glomerular diagnosis resulting in end-stage renal disease… 
Review
2004
Review
2004
Signaling at the slit diaphragm.
Diseases of the glomerular filter of the kidney are a leading cause of end-stage renal failure. Recent studies have emphasized… 
Highly Cited
2003
Highly Cited
2003
Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1.
Nephrin and NEPH1, the gene products of NPHS1 and NEPH1, are podocyte membrane proteins of the Ig superfamily. Similar to the… 
Highly Cited
2003
Highly Cited
2003
Nephrin and Neph1 Co-localize at the Podocyte Foot Process Intercellular Junction and Form cis Hetero-oligomers*
Glomerular visceral epithelial cells (podocytes) appear to play a central role in maintaining the selective filtration barrier of… 
Highly Cited
2003
Highly Cited
2003
Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability.
Neph1-deficient mice develop nephrotic syndrome at birth, indicating the importance of this protein in the development of a… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)