KIR2DL2 wt Allele

Known as: CD158B1, cl-43, NKAT6 
Human KIR2DL2 wild-type allele is located in the vicinity of 19q13.4 and is approximately 15 kb in length. This allele, which encodes killer cell… (More)
National Institutes of Health

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19q13.4Immune responseKIR2DL2 geneKIR2DL2 protein, human
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Papers overview

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2009
2009
Biomarkers of suppressed natural killer (NK) cell function in metastatic melanoma: decreased NKG2D and increased CD158a receptors on CD3-CD16+ NK cells.
In metastatic melanoma (MM) patients we evaluated natural killer (NK)-cell activity, distribution of several NK receptors and… (More)
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Highly Cited
2006
Highly Cited
2006
The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils.
Allergic, inflammatory, and immune responses carried out by eosinophils are regulated by the cross talk between activatory and… (More)
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2005
2005
Expression of killer immunoglobulin-like receptors on peripheral blood NK cell subsets of women with recurrent spontaneous abortions or implantation failures.
PROBLEM Decidual natural killer (NK) cells express inhibitory receptors (killer immunoglobulin-like receptors, KIRs), which bind… (More)
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2004
2004
Expression of chemokine and inhibitory receptors on natural killer cells: effect of immune activation and HIV viremia.
We examined the cell-surface expression of chemokine and natural killer (NK) cell inhibitory receptors (iNKRs) on NK cells from… (More)
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2001
2001
CD85/LIR-1/ILT2 and CD152 (cytotoxic T lymphocyte antigen 4) inhibitory molecules down-regulate the cytolytic activity of human CD4+ T-cell clones specific for Mycobacterium tuberculosis.
Antigen-specific cytolytic CD4+ T lymphocytes control Mycobacterium tuberculosis infection by secreting cytokines and by killing… (More)
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Highly Cited
1999
Highly Cited
1999
Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Valpha24-JalphaQ and gammadelta T…
The adult liver contains lymphocytes with a unique phenotypic distribution compared to blood and other organs. We have… (More)
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Highly Cited
1999
Highly Cited
1999
CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients.
In humans, NK receptors are expressed by natural killer cells and some T cells, the latter of which are preferentially… (More)
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1997
1997
Differential association of phosphatases with hematopoietic co-receptors bearing immunoreceptor tyrosine-based inhibition motifs.
A novel family of inhibitory co-receptors has been recently defined according to the presence in their intracytoplasmic domain of… (More)
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1997
1997
Peptides isolated from HLA-Cw*0304 confer different degrees of protection from natural killer cell-mediated lysis.
HLA class I molecules bind peptides derived from proteins degraded in the cytoplasm and display them for surveillance by the… (More)
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1997
1997
HLA-class I-specific inhibitory receptors in human cytolytic T lymphocytes: molecular characterization, distribution in lymphoid tissues and co-expression by individual T cells.
A subset of cytolytic T lymphocytes has been shown to express receptors of the NK type (NKR) which can inhibit T cell… (More)
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