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KDM4C gene

Known as: lysine demethylase 4C, KDM4C, GENE AMPLIFIED IN SQUAMOUS CELL CARCINOMA 1 
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia
Review
2013
Review
2013
KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells.
Lysine methylation is one of the most prominent histone posttranslational modifications that regulate chromatin structure… 
Highly Cited
2012
Highly Cited
2012
IDH mutation impairs histone demethylation and results in a block to cell differentiation
Recurrent mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 have been identified in gliomas, acute myeloid leukaemias (AML… 
Highly Cited
2012
Highly Cited
2012
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding proteins that play key roles in breast cancer… 
Highly Cited
2010
Highly Cited
2010
Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.
Selective inhibitors of Jumonji domain-containing protein (JMJD) histone demethylases are candidate anticancer agents as well as… 
Highly Cited
2009
Highly Cited
2009
Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer
Earlier, mapping of the 9p23–24 amplicon in esophageal cancer cell lines led us to the positional cloning of gene amplified in… 
Highly Cited
2009
Highly Cited
2009
Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.
Cancers of the upper aerodigestive tract (UADT) include malignant tumors of the oral cavity, pharynx, larynx, and esophagus and… 
Highly Cited
2007
Highly Cited
2007
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression
Posttranslational modifications of histones, such as methylation, regulate chromatin structure and gene expression. Recently… 
Highly Cited
2006
Highly Cited
2006
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3
Methylation of lysine and arginine residues on histone tails affects chromatin structure and gene transcription. Tri- and… 
Highly Cited
2000
Highly Cited
2000
Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines.
In a recent study, we identified frequent amplification of DNA copy number at chromosome 9p23-24 in cell lines derived from… 
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