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KDM4C gene

Known as: lysine demethylase 4C, KDM4C, GENE AMPLIFIED IN SQUAMOUS CELL CARCINOMA 1 
 
National Institutes of Health

Papers overview

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2016
2016
Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia
Summary Transcriptional deregulation plays a major role in acute myeloid leukemia, and therefore identification of epigenetic… Expand
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Highly Cited
2016
Highly Cited
2016
Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.
The orchestrated action of genes controls complex biological phenotypes, yet the systematic discovery of gene and drug… Expand
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Review
2013
Review
2013
KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells.
Lysine methylation is one of the most prominent histone posttranslational modifications that regulate chromatin structure… Expand
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Highly Cited
2012
Highly Cited
2012
IDH mutation impairs histone demethylation and results in a block to cell differentiation
Recurrent mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 have been identified in gliomas, acute myeloid leukaemias (AML… Expand
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Highly Cited
2010
Highly Cited
2010
Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.
Selective inhibitors of Jumonji domain-containing protein (JMJD) histone demethylases are candidate anticancer agents as well as… Expand
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Highly Cited
2009
Highly Cited
2009
Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.
Cancers of the upper aerodigestive tract (UADT) include malignant tumors of the oral cavity, pharynx, larynx, and esophagus and… Expand
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Highly Cited
2007
Highly Cited
2007
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression
Posttranslational modifications of histones, such as methylation, regulate chromatin structure and gene expression. Recently… Expand
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Highly Cited
2006
Highly Cited
2006
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3
Methylation of lysine and arginine residues on histone tails affects chromatin structure and gene transcription. Tri- and… Expand
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Highly Cited
2005
Highly Cited
2005
Genome-wide association study in esophageal cancer using GeneChip mapping 10K array.
Whole genome association studies of complex human diseases represent a new paradigm in the postgenomic era. In this study, we… Expand
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Highly Cited
2000
Highly Cited
2000
Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines.
In a recent study, we identified frequent amplification of DNA copy number at chromosome 9p23-24 in cell lines derived from… Expand
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