FAQ

KDM4C gene

Known as: lysine demethylase 4C, KDM4C, GENE AMPLIFIED IN SQUAMOUS CELL CARCINOMA 1 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2017
051020002017

Papers overview

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2016
2016
KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism.
The histone lysine demethylase KDM4C is often overexpressed in cancers primarily through gene amplification. The molecular… (More)
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2016
2016
Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia
Transcriptional deregulation plays a major role in acute myeloid leukemia, and therefore identification of epigenetic modifying… (More)
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Highly Cited
2012
Highly Cited
2012
IDH mutation impairs histone demethylation and results in a block to cell differentiation.
Recurrent mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 have been identified in gliomas, acute myeloid leukaemias (AML… (More)
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2012
2012
Identification and functional analysis of 9p24 amplified genes in human breast cancer
Previously, our group identified a novel amplicon at chromosome 9p24 in human esophageal and breast cancers, and cloned the novel… (More)
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2010
2010
Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.
Selective inhibitors of Jumonji domain-containing protein (JMJD) histone demethylases are candidate anticancer agents as well as… (More)
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Highly Cited
2009
Highly Cited
2009
Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer
Earlier, mapping of the 9p23–24 amplicon in esophageal cancer cell lines led us to the positional cloning of gene amplified in… (More)
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2008
2008
Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3.
PURPOSE The well-known translocations identified in MALT lymphomas include t(11;18)/API2-MALT1, t(1;14)/IGH-BCL10, and t(14;18… (More)
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2005
2005
Genome-wide association study in esophageal cancer using GeneChip mapping 10K array.
Whole genome association studies of complex human diseases represent a new paradigm in the postgenomic era. In this study, we… (More)
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2001
2001
A novel amplicon at 9p23 - 24 in squamous cell carcinoma of the esophagus that lies proximal to GASC1 and harbors NFIB.
The non-random amplification of DNA at 9p23 - 24 observed in various types of human cancers, including esophageal squamous cell… (More)
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Highly Cited
2000
Highly Cited
2000
Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines.
In a recent study, we identified frequent amplification of DNA copy number at chromosome 9p23-24 in cell lines derived from… (More)
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