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KCNK5 gene

Known as: K2p5.1, potassium two pore domain channel subfamily K member 5, KCNK5 
National Institutes of Health

Papers overview

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2007
2007
Up-regulated astroglial TWIK-related acid-sensitive K+ channel-1 (TASK-1) in the hippocampus of seizure-sensitive gerbils: A target of anti-epileptic drugs
2007
2007
Extracellular pH alkalinization by Cl-/HCO3- exchanger is crucial for TASK2 activation by hypotonic shock in proximal cell lines from mouse kidney.
We have previously shown that K(+)-selective TASK2 channels and swelling-activated Cl(-) currents are involved in a regulatory… 
Review
2007
Review
2007
Involvement of potassium and chloride channels and other transporters in volume regulation by spermatozoa.
Spermatozoa produced in the testis undergo maturation in the epididymis which secretes an osmolyte-rich fluid that bathes the… 
2006
2006
Investigation of the role of TASK‐2 channels in rat pulmonary arteries; pharmacological and functional studies following RNA interference procedures
In the present study, we investigated the ability of RNA interference technology to suppress TASK‐2 potassium channel expression… 
2005
2005
Na(+)-induced inward rectification in the two-pore domain K(+) channel, TASK-2.
TASK-2 is a member of the two-pore domain K(+) (K(2P)) channel family that is expressed at high levels in several epithelia… 
Highly Cited
2004
Highly Cited
2004
Selective block of the human 2‐P domain potassium channel, TASK‐3, and the native leak potassium current, IKSO, by zinc
Background potassium channels control the resting membrane potential of neurones and regulate their excitability. Two‐pore‐domain… 
2003
2003
CFTR-dependent and -independent swelling-activated K+ currents in primary cultures of mouse nephron.
The role of CFTR in the control of K(+) currents was studied in mouse kidney. Whole cell clamp was used to identify K(+) currents… 
2003
2003
Extracellular conserved cysteine forms an intersubunit disulphide bridge in the KCNK5 (TASK-2) K + channel without having an essential effect upon activity
The functional channel unit of K + channels with two pore regions in tandem is thought to be a homodimer and it has been… 
Highly Cited
2002
Highly Cited
2002
TASK-1, TASK-2, TASK-3 and TRAAK immunoreactivities in the rat carotid body
Highly Cited
2000
Highly Cited
2000
Volatile Anesthetics Activate the Human Tandem Pore Domain Baseline K+ Channel KCNK5
Background Previous studies have identified a volatile anesthetic–induced increase in baseline potassium permeability and… 
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