Volatile Anesthetics Activate the Human Tandem Pore Domain Baseline K+ Channel KCNK5

@article{Gray2000VolatileAA,
  title={Volatile Anesthetics Activate the Human Tandem Pore Domain Baseline K+ Channel KCNK5},
  author={A. Gray and B. B. Zhao and C. Kindler and B. Winegar and M. J. Mazurek and J. Xu and R. Chavez and J. Forsayeth and C. Yost},
  journal={Anesthesiology},
  year={2000},
  volume={92},
  pages={1722-1730}
}
  • A. Gray, B. B. Zhao, +6 authors C. Yost
  • Published 2000
  • Medicine
  • Anesthesiology
  • Background Previous studies have identified a volatile anesthetic–induced increase in baseline potassium permeability and concomitant neuronal inhibition. The emerging family of tandem pore domain potassium channels seems to function as baseline potassium channels in vivo. Therefore, we studied the effects of clinically used volatile anesthetics on a recently described member of this family. Methods A cDNA clone containing the coding sequence of KCNK5 was isolated from a human brain library… CONTINUE READING
    73 Citations
    Amide Local Anesthetics Potently Inhibit the Human Tandem Pore Domain Background K+ Channel TASK-2 (KCNK5)
    • 63
    • PDF
    Anesthetic-sensitive 2P Domain K+ Channels
    • 96
    • Highly Influenced
    • PDF
    The TASK-1 Two-Pore Domain K+ Channel Is a Molecular Substrate for Neuronal Effects of Inhalation Anesthetics
    • 242
    • Highly Influenced
    • PDF
    Therapeutic potential of neuronal two-pore domain potassium-channel modulators.
    • 87
    • PDF
    Two-Pore-Domain (Kcnk) Potassium Channels: Dynamic Roles in Neuronal Function
    • 140

    References

    SHOWING 1-10 OF 58 REFERENCES
    An Open Rectifier Potassium Channel with Two Pore Domains in Tandem Cloned from Rat Cerebellum
    • 244
    • PDF
    A Novel Subunit for Shal K+ Channels Radically Alters Activation and Inactivation
    • 73
    • PDF
    A pH-sensitive Yeast Outward Rectifier K Channel with Two Pore Domains and Novel Gating Properties (*)
    • 109
    • PDF
    TWIK-2, a New Weak Inward Rectifying Member of the Tandem Pore Domain Potassium Channel Family*
    • 130
    • PDF