Volatile Anesthetics Activate the Human Tandem Pore Domain Baseline K+ Channel KCNK5

  title={Volatile Anesthetics Activate the Human Tandem Pore Domain Baseline K+ Channel KCNK5},
  author={A. Gray and B. B. Zhao and C. Kindler and B. Winegar and M. J. Mazurek and J. Xu and R. Chavez and J. Forsayeth and C. Yost},
  • A. Gray, B. B. Zhao, +6 authors C. Yost
  • Published 2000
  • Medicine
  • Anesthesiology
  • Background Previous studies have identified a volatile anesthetic–induced increase in baseline potassium permeability and concomitant neuronal inhibition. The emerging family of tandem pore domain potassium channels seems to function as baseline potassium channels in vivo. Therefore, we studied the effects of clinically used volatile anesthetics on a recently described member of this family. Methods A cDNA clone containing the coding sequence of KCNK5 was isolated from a human brain library… CONTINUE READING
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