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An Open Rectifier Potassium Channel with Two Pore Domains in Tandem Cloned from Rat Cerebellum
TLDR
It is established that rTASK is a baseline potassium channel that satisfies the Goldman–Hodgkin–Katz current equation for an open channel and can be classified an open rectifier. Expand
Cloning and functional expression of a human liver organic cation transporter.
TLDR
The functional expression of hOCT1 will provide a powerful tool for elucidation of the mechanisms of organic cation transport in the human liver and understanding of the mechanism involved in the disposition and hepatotoxicity of drugs. Expand
Dual Effects of Anandamide on NMDA Receptor‐Mediated Responses and Neurotransmission
TLDR
Examination of rat brain slices demonstrates that anandamide can modulate NMDA receptor activity in addition to its role as a cannabinoid receptor ligand. Expand
Glutamine Uptake by Neurons: Interaction of Protons with System A Transporters
TLDR
It is shown that SA1 and SA2 do not couple H+ movement to amino acid flux, and differences between System N and A transporters in coupling to H+ thus contribute to the delivery of glutamine from glia to neurons. Expand
Amino acid transport system A resembles system N in sequence but differs in mechanism.
TLDR
The isolation of a cDNA encoding System A that shows close similarity to the recently identified System N transporter (SN1), which shares many functional characteristics, including a marked sensitivity to low pH, but, unlike SN1, SA1 does not mediate proton exchange. Expand
TWIK-2, a New Weak Inward Rectifying Member of the Tandem Pore Domain Potassium Channel Family*
TLDR
A new clone reveals the existence of a subfamily in the tandem pore domain potassium channel family with weak inward rectification properties, which is most closely related to TWIK-1 and expressed heterologously in Xenopus oocytes. Expand
Local anesthetic inhibition of baseline potassium channels with two pore domains in tandem.
TLDR
Local anesthetics inhibit tandem pore domain baseline potassium channels, and they could depolarize the resting membrane potential of cells expressing these channels. Expand
Mechanosensitivity of the lower extremity nervous system during straight-leg raise neurodynamic testing in healthy individuals.
TLDR
These findings support the hypothesis that addition of ankle dorsiflexion during straight-leg raise testing induces earlier distal muscle activation and reduces hip flexion motion. Expand
Inhaled Anesthetics and Immobility: Mechanisms, Mysteries, and Minimum Alveolar Anesthetic Concentration
TLDR
Understanding of where and how inhaled anesthetics act to produce immobility by actions on the spinal cord is advanced, but in vivo studies to date suggest that several channels or receptors may not be mediators. Expand
Volatile Anesthetics Activate the Human Tandem Pore Domain Baseline K+ Channel KCNK5
TLDR
Human KCNK5 is a tandem pore domain potassium channel exhibiting delayed activation and sensitivity to volatile anesthetics and may therefore have a role in suppressing cellular excitability during general anesthesia. Expand
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