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Jumonji Domain-Containing Histone Demethylases

Known as: JmjC Domain-Containing Histone Demethylases, Jumonji Domain-Containing Histone Demethylases [Chemical/Ingredient], Jumonji Domain Containing Histone Demethylases 
A family of histone demethylases that share a conserved Jumonji C domain. The enzymes function via an iron-dependent dioxygenase mechanism that… 
National Institutes of Health

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IBM1 protein, ArabidopsisIBM2 protein, ArabidopsisJHD2 protein, S cerevisiaeJmjd2c protein, mouse
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Human histone demethylase KDM6B can catalyse sequential oxidations† †Electronic supplementary information (ESI) available: Procedures for synthesis of lysine analogues, solid phase peptide synthesis…
Biochemical studies on the histone lysyl demethylase KDM6B reveal it is capable of catalysing reactions on multiple lysine… 
2017
2017
JARID1/KDM5 demethylases as cancer targets?
In cancer, where the balance between proliferation and differentiation is disturbed, changes in the epigenome occur, some of… 
2017
2017
Probing the Charge and Conformational Requirements of JmjC Demethylases
2016
2016
Purification, Biochemical Analysis, and Structure Determination of JmjC Lysine Demethylases.
2015
2015
Abstract 108: Inhibition of demethylase, JMJD3 sensitizes diffuse large B-cell lymphoma (DLBCL) to chemotherapy
Introduction Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin9s lymphoma (NHL) representing more than… 
Highly Cited
2012
Highly Cited
2012
Kinetic analysis of iron-dependent histone demethylases: α-ketoglutarate substrate inhibition and potential relevance to the regulation of histone demethylation in cancer cells.
The Jumonji C domain-containing histone demethylases (JmjC-HDMs) are α-ketoglutarate (αKG)-dependent, O(2)-activating, non-heme… 
2012
2012
Expression and significance of histone H3K27 demethylases in renal cell carcinoma
The histone H3K27 demethylases UTX and JMJD3 are important regulatory factors that modulate gene expression by altering the… 
2010
2010
The JmjN Domain of Jhd 2 Is Important for Its Protein Stability , and the Plant Homeodomain ( PHD ) Finger Mediates Its Chromatin Association Independent of H 3 K 4 Methylation *
Histone lysine methylation is a dynamic process that plays an important role in regulating chromatin structure and gene… 
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