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JNJ-40346527
Known as:
FMS Inhibitor JNJ-40346527
A small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. FMS…
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National Institutes of Health
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Related topics
Related topics
5 relations
Broader (2)
Imidazoles
Pyridines
Inhibition of Cell Proliferation
Receptor Tyrosine Kinase Inhibition
Signal Transduction Inhibition
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
R. Mancuso
,
Gemma L. Fryatt
,
+140 authors
V. Perry
Brain : a journal of neurology
2019
Corpus ID: 202554611
Microglia have been implicated in amyloid beta-induced neuropathology, but their role in tau-induced neurodegeneration remains…
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2019
2019
The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitis
C. Manthey
,
B. Moore
,
+9 authors
S. Plevy
PloS one
2019
Corpus ID: 207964412
Background & aims Originally believed to be primarily a disorder of T-cell signaling, evidence shows that macrophage-lineage…
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Review
2018
Review
2018
Recent advances in colony stimulating factor-1 receptor/c-FMS as an emerging target for various therapeutic implications.
A. Kumari
,
O. Silakari
,
R. Singh
Biomedicine & pharmacotherapy = Biomedecine…
2018
Corpus ID: 5038067
2016
2016
Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatin
H. Pass
,
C. Lavilla
,
+5 authors
M. Cioce
Oncotarget
2016
Corpus ID: 15844723
In the present work we show that multiple lung cancer cell lines contain cisplatin resistant cell subpopulations expressing the…
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Highly Cited
2015
Highly Cited
2015
An Open-Label, Multicenter, Phase I/II Study of JNJ-40346527, a CSF-1R Inhibitor, in Patients with Relapsed or Refractory Hodgkin Lymphoma
B. von Tresckow
,
F. Morschhauser
,
+7 authors
A. Engert
Clinical Cancer Research
2015
Corpus ID: 444487
Purpose: This phase I/II study investigated JNJ-40346527, a selective inhibitor of the colony-stimulating factor-1 receptor (CSF…
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2015
2015
Results from a Phase IIA Parallel Group Study of JNJ-40346527, an Oral CSF-1R Inhibitor, in Patients with Active Rheumatoid Arthritis despite Disease-modifying Antirheumatic Drug Therapy
M. Genovese
,
E. Hsia
,
+8 authors
A. Greenspan
The Journal of Rheumatology
2015
Corpus ID: 22576643
Objective. To assess the efficacy and safety of JNJ-40346527, a selective inhibitor of colony-stimulating factor-1 (CSF-1…
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2014
2014
THU0133 Results from A Phase 2A, Randomized, Multicenter, Double-Blind, Placebo-Controlled, Parallel-Group Study of Jnj-40346527, an Oral CSF-1R Inhibitor, in Patients with Active Rheumatoid…
M. Genovese
,
E. Hsia
,
+7 authors
A. Greenspan
2014
Corpus ID: 75289565
Background JNJ-40346527, an investigational agent, is a selective inhibitor of the colony stimulating factor-1 receptor (CSF-1R…
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Review
2013
Review
2013
A Phase 1 Study Of JNJ-40346527, a Colony Stimulating Factor-1 Receptor (CSF-1R) Inhibitor, In Patients With Relapsed Or Refractory Hodgkin Lymphoma
B. Tresckow
,
F. Morschhauser
,
+8 authors
A. Engert
2013
Corpus ID: 68375289
Introduction JNJ-40346527 is a selective inhibitor of the colony stimulating factor-1 receptor (CSF-1R) tyrosine kinase. It…
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