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J 104132

Known as: J-104132 
National Institutes of Health

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3 relations

Broader (2)

Endothelin receptor antagonistPyridines
L 753037

Papers overview

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2011
2011
Endothelin ETB Receptor Is Involved in Sex Differences in the Development of Balloon Injury-Induced Neointimal Formation
The purpose of this study was to evaluate the involvement of endothelin (ET)B receptor-mediated action in the sex differences in… 
2009
2009
Inhibition of Endothelin ETB Receptor System Aggravates Neointimal Hyperplasia after Balloon Injury of Rat Carotid Artery
Endothelin-1 (ET)/ETA receptor system has been known to play an important role in the pathogenesis of neointimal hyperplasia… 
2004
2004
Hepatobiliary Transport of a Nonpeptidic Endothelin Antagonist, (+)-(5S,6R, 7R)-2-Butyl-7-[2((2S)-2-Carboxypropyl)-4-Methoxyphenyl]-5-(3,4-Methylenedioxyphenyl) Cyclopentenol[1,2-b]Pyridine-6…
AbstractPurpose. Hepatobiliary excretions of drugs from the blood to the bile include two essential transmembrane processes… 
Highly Cited
2002
Highly Cited
2002
Effects of chronic administration of the novel endothelin antagonist J‐104132 on endothelial dysfunction in streptozotocin‐induced diabetic rat
The biosynthesis of endothelin‐1 is increased in the diabetic state. So this peptide may cause diabetic vascular complications… 
2002
2002
ects of chronic administration of the novel endothelin antagonist J-104132 on endothelial dysfunction in streptozotocin-induced diabetic rat
1 The biosynthesis of endothelin-1 is increased in the diabetic state. So this peptide may cause diabetic vascular complications… 
2001
2001
Pathophysiological roles of endogenous endothelin-1 in dogs with chronic heart failure produced by rapid right ventricular pacing.
This study was designed to analyze the pathophysiological role of the endogenous endothelin (ET) system and the therapeutic… 
2000
2000
Antihypertensive effects of a mixed endothelin-A- and -B-receptor antagonist, J-104132, were augmented in the presence of an AT1 -receptor antagonist, MK-954.
The single oral administration of a mixed endothelin-A-and -B- (ETA/ETB) receptor antagonist, J-104132 (L-753,037) decreased the… 
1999
1999
Pharmacological properties of J-104132 (L-753,037), a potent, orally active, mixed ETA/ETB endothelin receptor antagonist.
J-104132 [(+)-(5S,6R, 7R)-2-butyl-7-[2-((2S)-2-carboxypropyl)-4-methoxyphenyl]-5-(3, 4-methylenedioxyphenyl)cyclopenteno[1,2-b… 
1999
1999
Pathophysiological roles of endothelin-1 in Dahl salt-sensitive hypertension.
The purpose of the present experiment was to study the pathophysiological roles of endothelin-1 (ET-1) in salt-sensitive… 
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