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Ivermectin

Known as: Ivermectin [Chemical/Ingredient], Ivermectina, Ivermectinum 
A macrocyclic lactone derived from Streptomyces avermitilis with antiparasitic activity. Ivermectin exerts its anthelmintic effect via activating… Expand
National Institutes of Health

Related topics

Related topics

43 relations

Narrower (16)

6,8a-seco-6,8a-deoxyavermectin B1a aglyconeDuraMectinMectizanParid
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Antiparasitic AgentsAscariasisEnterobiasisIn Blood
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Broader (1)

Insecticides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer
The strategy of using existing drugs originally developed for one disease to treat other indications has found success across… Expand
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Review
2018
Review
2018
The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug.
Drug repositioning is a highly studied alternative strategy to discover and develop anticancer drugs. This drug development… Expand
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Review
2018
Review
2018
ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector…
BACKGROUND The present review is part of the ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document… Expand
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Highly Cited
2001
Highly Cited
2001
Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene.
A subpopulation of collie dogs is extremely sensitive to neurotoxicity induced by ivermectin. The aim of this study was to… Expand
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Highly Cited
2000
Highly Cited
2000
The genetics of ivermectin resistance in Caenorhabditis elegans.
The ability of organisms to evolve resistance threatens the effectiveness of every antibiotic drug. We show that in the nematode… Expand
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Highly Cited
1998
Highly Cited
1998
Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor.
We report that preapplication of ivermectin, in the micromolar range, strongly enhances the subsequent acetylcholine-evoked… Expand
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Highly Cited
1998
Highly Cited
1998
Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog.
Resistance to ivermectin and related drugs is an increasing problem for parasite control. The mechanism of ivermectin resistance… Expand
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Highly Cited
1994
Highly Cited
1994
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
We have generated mice homozygous for a disruption of the mdr1a (also called mdr3) gene, encoding a drug-transporting P… Expand
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Highly Cited
1987
Highly Cited
1987
Environmental consequences of treating cattle with the antiparasitic drug ivermectin
Ivermectin (22,23-dihydroavermectin B1) is a recently discovered, persistent, broad-spectrum, antiparasitic drug of unpredecented… Expand
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Highly Cited
1983
Highly Cited
1983
Ivermectin: a potent new antiparasitic agent.
Ivermectin is the 22,23-dihydro derivative of avermectin B1, a macrocyclic lactone produced by an actinomycete, Streptomyces… Expand
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