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Isoflurophate

Known as: Diisopropoxyphosphoryl Fluoride, Diisopropylphosphorofluoridate, Phosphorofluoridic acid, bis(1-methylethyl) ester 
A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.
National Institutes of Health

Related topics

Related topics

19 relations

Broader (3)

Cholinesterase InhibitorsProtease Inhibitorsalkylphosphate
Drug AllergyGlaucomaIn BloodParasympathomimetic Agents

Narrower (3)

DyflosFloroprylmipafox

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1987
Highly Cited
1987
Identification of regions of alpha-thrombin involved in its interaction with hirudin.
The contributions of various regions of human alpha-thrombin to the formation of the tight complex with hirudin have been… 
Highly Cited
1979
Highly Cited
1979
Characterization of "thyroliberin-deamidating enzyme" as a post-proline-cleaving enzyme. Partial purification and enzyme-chemical analysis of the enzyme from anterior pituitary tissue.
An enzyme which catalyzes the deamidation of thyroliberin (TRF; less than Glu-His-Pro-NH2) has been purified 110-fold from… 
Highly Cited
1976
Highly Cited
1976
One-step purification and properties of a two-peptide fatty acid synthetase from the uropygial gland of the goose.
Cell-free extracts from the uropygial gland of goose catalyzed the incorporation of malonyl-CoA into normal fatty acids and… 
Highly Cited
1975
Highly Cited
1975
Factor-VIII-related antigen: multiple molecular forms in human plasma.
Analysis of Factor-VIII-related antigen (vWAg) in normal plasma by crossed immunoelectrophoresis reveals an asymmetric pattern… 
Highly Cited
1966
Highly Cited
1966
Measurement of the affinity and phosphorylation constants governing irreversible inhibition of cholinesterases by di-isopropyl phosphorofluoridate.
1. A procedure is described for determining the affinity constant K(a) and the phosphorylation constant k(p) for the inhibition… 
Highly Cited
1966
Highly Cited
1966
Dealkylation studies on inhibited acetylcholinesterase.
1. A rapid method for measuring the rate of dealkylation of organophosporus-inhibited enzymes is described. 2. The dealkylation… 
Highly Cited
1964
Highly Cited
1964
INHIBITION OF CHYMOTRYPSIN ACTIVITY IN CRYSTALLINE TRYPSIN PREPARATIONS.
Investigations of protein structures have made extensive use of trypsin to obtain specific cleavage of the peptide chains at the… 
Highly Cited
1959
Highly Cited
1959
Intestinal absorption of insulin in the rat.
The intestinal absorption of insulin in the rat has been investigated. Amorphous zinc-free insulin and proteolytic inhibitors… 
Highly Cited
1955
Highly Cited
1955
Cholinergic mechanism involved in function of mesodiencephalic activating system.
A previous investigation 1 dealt with the action of cholinergic drugs and of atropine on the electrical activity of the rabbit… 
Highly Cited
1949
Highly Cited
1949
The measurement of the cytochrome oxidase activity of enzyme preparations.
containing 1 ml. 15 % glycerol solution, 1-0 ml. 0-1 M-sodium acetate, 0-5 ml. 0-3 M-bicarbonate solution and 0 5 ml. of the… 
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