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Isocarboxazid
Known as:
Isocarboxazid [Chemical/Ingredient]
, Isocarboxazide
, 3-Isoxazolecarboxylic acid, 5-methyl-, 2-(phenylmethyl)hydrazide
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A hydralazine and monoamine oxidase (MAO) inhibitor with antidepressant activity. Isocarboxazid blocks the breakdown (oxidative deamination) of…
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National Institutes of Health
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Related topics
Related topics
19 relations
Broader (2)
Antidepressive Agents
Monoamine Oxidase Inhibitors
Cerebrovascular Disorders
Depressive disorder
Drug Allergy
Hypertensive disease
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Narrower (2)
Isocarboxazid Oral Tablet [Marplan]
Marplan
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Assessment of the anticholinergic effects of antidepressants in a single-dose cross-over study of salivation and plasma levels
L. Clemmesen
,
P. L. Mikkelsen
,
H. Lund
,
T. Bolwig
,
O. Rafaelsen
Psychopharmacology
2004
Corpus ID: 5970487
In order to evaluate the anticholinergic effect of antidepressant drugs, 11 healthy volunteers were given single oral doses of…
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Highly Cited
1984
Highly Cited
1984
The importance of dose in isocarboxazid therapy.
J. Davidson
,
C. Turnbull
Journal of Clinical Psychiatry
1984
Corpus ID: 42746741
Little information is available on the effectiveness and safety of particular doses of isocarboxazid. In a study using…
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1984
1984
MAO inhibitor therapy in trichotillomania associated with depression: case report.
R. Krishnan
,
J. Davidson
,
R. Miller
Journal of Clinical Psychiatry
1984
Corpus ID: 30391500
Trichotillomania may sometimes be an atypical variant of depressive illness. A case is reported in which the MAO inhibitor…
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1983
1983
Isocarboxazid in the treatment of depression.
S. Zisook
American Journal of Psychiatry
1983
Corpus ID: 41532422
Of 50 outpatients with nonpsychotic, nonmelancholic, anxious depression, the 24 patients taking isocarboxazid had better scores…
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1982
1982
Genotoxic activity of five antidepressant hydrazines in a battery of in vivo and in vitro short-term tests.
G. Brambilla
,
M. Cavanna
,
+6 authors
S. De Flora
Journal of Toxicology and Environmental Health…
1982
Corpus ID: 1284623
Five antidepressant agents (monoamine oxidase inhibitors) having a hydrazino group--phenelzine, nialamide, mebanazine…
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1978
1978
Sensitization to the generalized Shwartzman reaction by catechol-O-methyltransferase inhibitors.
J. Latour
,
C. Láger-Gauthier
American Journal of Pathology
1978
Corpus ID: 26063238
The generalized Shwartzman reaction (GSR) was produced by a single injection of endotoxin in male rats pretreated with catechol-o…
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1974
1974
Histamine methylation in vivo and in vitro
R. Schayer
Agents and Actions
1974
Corpus ID: 38246031
modify the levels of all-histamine and 3Hmethylhistamine. On the contrary, isocarboxazide, a monoamineoxidase inhibitor, markedly…
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1972
1972
Primary hyperoxaluria with normal alpha-ketoglutarate: glyoxylate carboligase activity. Treatment with isocarboxazid.
E. Bourke
,
G. Frindt
,
P. Flynn
,
G. Schreiner
Annals of Internal Medicine
1972
Corpus ID: 30357333
Abstract A 10-year-old girl with primary hyperoxaluria, calcium oxalate nephrolithiasis, and normal blood urea was studied…
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1961
1961
Chlorprothixine (Taractan) and isocarboxazid (Marplan) in psychotic depressions.
H. F. Darling
American Journal of Psychiatry
1961
Corpus ID: 42433179
Of the 2 drugs, Marplan seems more indicated as the drug of choice for the nonagitated endogenous depression, Taractan for…
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1959
1959
Isocarboxazid (marplan) in ambulatory psychiatric patients.
H. F. Darling
American Journal of Psychiatry
1959
Corpus ID: 28370762
Isocarboxazid appears to be a very workable hydrazine derivative for treating ambulatory depressions, and is of use as well in…
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