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Isocarboxazid

Known as: Isocarboxazid [Chemical/Ingredient], Isocarboxazide, 3-Isoxazolecarboxylic acid, 5-methyl-, 2-(phenylmethyl)hydrazide 
A hydralazine and monoamine oxidase (MAO) inhibitor with antidepressant activity. Isocarboxazid blocks the breakdown (oxidative deamination) of… 
National Institutes of Health

Related topics

Related topics

19 relations

Broader (2)

Antidepressive AgentsMonoamine Oxidase Inhibitors
Cerebrovascular DisordersDepressive disorderDrug AllergyHypertensive disease

Narrower (2)

Isocarboxazid Oral Tablet [Marplan]Marplan

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Current Place of Monoamine Oxidase Inhibitors in the Treatment of Depression
This paper reviews the discovery and history of the use of irreversible monoamine oxidase (MAO) inhibitors (MAOIs) such as… 
Highly Cited
1998
Highly Cited
1998
Listening to Prozac but Hearing Placebo: A Meta-Analysis of Antidepressant Medication
Mean effect sizes for changes in depression were calculated for 2,318 patients who had been randomly assigned to either… 
Review
1995
Review
1995
MAOIs in the Contemporary Treatment of Depression
1991
1991
Moclobemide in depression: a randomized, multicentre trial against isocarboxazide and clomipramine emphasizing atypical depression
Moclobemide was compared with isocarboxazide and clomipramine in patients with depression. A total of 167 outpatients were… 
Highly Cited
1988
Highly Cited
1988
A trial of isocarboxazid in the treatment of bulimia nervosa.
Eighteen women completed a double-blind, placebo-controlled crossover study designed to investigate the effects of isocarboxazid… 
Highly Cited
1988
Highly Cited
1988
An efficacy study of isocarboxazid and placebo in depression, and its relationship to depressive nosology.
Isocarboxazid and placebo were evaluated in 130 anxious depressives. Drug was superior to placebo on depression, anxiety… 
Highly Cited
1968
Highly Cited
1968
DNA damage caused by antidepressant hydrazines and related drugs.
Highly Cited
1966
Highly Cited
1966
An electrophysiological study of 5‐hydroxytryptamine receptors of neurones in the molluscan nervous system
1. 5‐Hydroxytryptamine (5‐HT) has been iontophoretically applied to the membrane of central neurones of Cryptomphallus aspersa… 
1963
1963
Reserpine, monoamine oxidase inhibitors, and distribution of biogenic amines in monkey brain.
Highly Cited
1962
Highly Cited
1962
Drug therapy in depressions: Controlled evaluation of imipramine, isocarboxazide, dextroamphetamine‐amobarbital, and placebo
An evaluation of imipramine, isocarboxazide, dextroamphetamine‐amobarbital, and placebo was carried out in 204 patients with… 
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