Assessment of the anticholinergic effects of antidepressants in a single-dose cross-over study of salivation and plasma levels

@article{Clemmesen2004AssessmentOT,
  title={Assessment of the anticholinergic effects of antidepressants in a single-dose cross-over study of salivation and plasma levels},
  author={Lars Clemmesen and P. L. Mikkelsen and H Lund and Tom Gert Bolwig and Ole J. Rafaelsen},
  journal={Psychopharmacology},
  year={2004},
  volume={82},
  pages={348-354}
}
In order to evaluate the anticholinergic effect of antidepressant drugs, 11 healthy volunteers were given single oral doses of reference drug, test drugs or placebo on a double-blind basis at weekly intervals. The doses corresponded to average daily patient medications. Spontaneous whole mouth and parotid salivation, and plasma levels of drug and possible metabolites were measured 2, 6 and 10h after drug administration.Moderate, statistically significant inhibition of salivation was found when… 

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