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Interleukin-7 Receptor alpha Subunit

Known as: CDw127, CD127 Antigen, Interleukin-7 Receptor Subunit Alpha 
Interleukin-7 receptor subunit alpha (459 aa, ~52 kDa) is encoded by the human IL7R gene. This protein is involved in both interleukin binding and… 
National Institutes of Health

Related topics

Related topics

19 relations
Cytokine Receptor GeneCytokine Signaling ProcessIL7 Signaling PathwayIL7R gene

Broader (1)

Interleukin 7 Receptor

Papers overview

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2020
2020
Phenotypic shift of small intestinal intra‐epithelial type 1 innate lymphoid cells in celiac disease is associated with enhanced cytotoxic potential
The small intestinal (SI) epithelium harbors a heterogeneous population of lymphocytes that mediate mucosal damage and repair in… 
Highly Cited
2018
Highly Cited
2018
Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine
Innate lymphoid cells (ILCs) are abundant in mucosal tissues and involved in tissue homeostasis and barrier function. Although… 
2014
2014
Human Lymphoid Development in the Absence of Common γ-Chain Receptor Signaling
Despite the power of model systems to reveal basic immunologic mechanisms, critical differences exist between species that… 
Review
2012
Review
2012
The human IL-7 receptor gene: deletions, polymorphisms and mutations.
Review
2012
Review
2012
Pathogenesis of multiple sclerosis via environmental and genetic dysregulation of N-glycosylation
Autoimmune diseases such as multiple sclerosis (MS) result from complex and poorly understood interactions of genetic and… 
Highly Cited
2011
Highly Cited
2011
Runx1/Cbfβ2 Complexes Are Required for Lymphoid Tissue Inducer Cell Differentiation at Two Developmental Stages
Hematopoietic lymphoid tissue inducer (LTi) cells are essential for the development of secondary lymphoid tissues including lymph… 
2011
2011
The interleukin‐7 receptor α chain contributes to altered homeostasis of regulatory T cells in multiple sclerosis
Treg homeostasis is disturbed in multiple sclerosis (MS). Frequencies of recent thymic emigrant (RTE)‐Treg are reduced and the… 
2008
2008
MEK1/2 Induces STAT5-Mediated Germline Transcription of the TCRγ Locus in Response to IL-7R Signaling1
The IL-7R plays an essential role in γδ T cell development by inducing V-J recombination of the TCRγ locus through STAT5… 
1997
1997
IL-7 induces proliferation, variable cytokine-producing ability and IL-2 responsiveness in naive CD4+ T-cells from human cord blood.
1997
1997
Absence of the IL-7 receptor component CDw127 indicates that gamma(c) expression alone is insufficient for IL-7 to modulate human neutrophil responses.
It has been proposed that neutrophils are targets for interleukin-7 (IL-7) because this cytokine was found to increase the number… 
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