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Interleukin-3 Receptor alpha Subunit

Known as: Interleukin-3 Receptor alpha Chain, Antigen, CD123, CD123 
A low affinity interleukin-3 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for… 
National Institutes of Health

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CD123 Ag:PrThr:Pt:Tiss:Ord:Immune stainIL3RA geneIn Bloodagonists

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IL3RA protein, human

Papers overview

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Highly Cited
2017
Highly Cited
2017
Characterization of SGN-CD123A, A Potent CD123-Directed Antibody–Drug Conjugate for Acute Myeloid Leukemia
Treatment choices for acute myelogenous leukemia (AML) patients resistant to conventional chemotherapies are limited and novel… 
Highly Cited
2016
Highly Cited
2016
Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells
Agger et al. show that Jmjd2/Kdm4 activities are required for MLL-AF9 translocated AML. Expression of the interleukin 3 receptor… 
Highly Cited
2016
Highly Cited
2016
Immunoprofiling of leukemic stem cells CD34+/CD38−/CD123+ delineate FLT3/ITD-positive clones
BackgroundAcute myeloid leukemia (AML) is a heterogeneous clonal disorder presenting with accumulation of proliferating… 
Review
2011
Review
2011
Monoclonal antibody therapy directed against human acute myeloid leukemia stem cells
Accumulating evidence indicates that many human cancers are organized as a cellular hierarchy initiated and maintained by self… 
Highly Cited
2006
Highly Cited
2006
Receptor Cross-Linking on Human Plasmacytoid Dendritic Cells Leads to the Regulation of IFN-α Production1
Plasmacytoid dendritic cells (PDC) are the natural type I IFN-producing cells that produce large amounts of IFN-α in response to… 
Highly Cited
2003
Highly Cited
2003
Modification of Promyelocytic Leukemia Zinc Finger Protein (PLZF) by SUMO-1 Conjugation Regulates Its Transcriptional Repressor Activity*
Promyelocytic leukemia zinc finger (PLZF) protein is a sequence-specific DNA-binding protein that represses the transcriptional… 
Highly Cited
2002
Highly Cited
2002
Interleukin-3 and interferon beta cooperate to induce differentiation of monocytes into dendritic cells with potent helper T-cell stimulatory properties.
It was observed that interferon beta (IFN-beta) prevents the down-regulation of the interleukin-3 receptor alpha chain (IL… 
Highly Cited
2001
Highly Cited
2001
Identification of a leukemic counterpart of the plasmacytoid dendritic cells.
This work aims to demonstrate that CD4(+)CD56(+) malignancies arise from transformed cells of the lymphoid-related plasmacytoid… 
Review
2001
Review
2001
CD123 (interleukin 3 receptor alpha chain).
1995
1995
The murine interleukin-3 receptor alpha subunit gene: chromosomal localization, genomic structure, and promoter function.
The interleukin-3 receptor (IL-3R) is composed of alpha and beta subunits, members of the class I cytokine receptor family. Here… 
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