Identification of a leukemic counterpart of the plasmacytoid dendritic cells.

  title={Identification of a leukemic counterpart of the plasmacytoid dendritic cells.},
  author={Laurence Chaperot and N Bendriss and Olivier Manches and R{\'e}my Gressin and Marck Maynadi{\'e} and Franck Trimoreau and Hubert Orfeuvre and Bernadette Corront and Jean Feuillard and Jean Jacques Sotto and Jean Claude Bensa and Francine Bri{\`e}re and Joel Plumas and Marie Christine Jacob},
  volume={97 10},
This work aims to demonstrate that CD4(+)CD56(+) malignancies arise from transformed cells of the lymphoid-related plasmacytoid dendritic cell (pDC) subset. The analysis of malignant cells from 7 patients shows that in all cases, like pDCs, leukemic cells are negative for lineage markers CD3, CD19, CD13, CD33, and CD11c but express high levels of interleukin-3 receptor alpha chain (IL-3Ralpha), HLA-DR, and CD45RA. Tumor cells produce interferon-alpha in response to influenza virus, while upon… CONTINUE READING
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