Interleukin-27

Known as: IL-17D, Interleukin 27, Interleukin-27 [Chemical/Ingredient] 
A heterodimeric cytokine composed of the IL-27p28 and EBI3 subunits. It is produced primarily by antigen-presenting cells after stimulation by… (More)
National Institutes of Health

Papers overview

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Review
2015
Review
2015
Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune response. Although it was initially linked… (More)
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Highly Cited
2012
Highly Cited
2012
Interleukin-27 (IL-27) is a key immunosuppressive cytokine that counters T helper 17 (Th17) cell-mediated pathology. To identify… (More)
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Highly Cited
2009
Highly Cited
2009
Despite their central function in orchestrating immunity, dendritic cells (DCs) can respond to inhibitory signals by becoming… (More)
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Highly Cited
2008
Highly Cited
2008
OBJECTIVE To investigate the potential role of interleukin (IL) 27 in rheumatoid arthritis (RA) by examining the expression of… (More)
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Highly Cited
2007
Highly Cited
2007
Excessive inflammation occurs during infection and autoimmunity in mice lacking the α-subunit of the interleukin 27 (IL-27… (More)
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Highly Cited
2007
Highly Cited
2007
IL-27 has been shown to play a suppressive role in experimental autoimmune encephalomyelitis (EAE) as demonstrated by more severe… (More)
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Highly Cited
2006
Highly Cited
2006
Interleukin 27 (IL-27) was first characterized as a proinflammatory cytokine with T helper type 1–inducing activity. However… (More)
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Highly Cited
2006
Highly Cited
2006
Studies have focused on the events that influence the development of interleukin 17 (IL-17)–producing T helper cells (TH-17 cells… (More)
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Highly Cited
2006
Highly Cited
2006
The immune response to bacterial infections must be tightly controlled to guarantee pathogen elimination while preventing tissue… (More)
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Highly Cited
2004
Highly Cited
2004
Although much promising data that interleukin (IL)-12 could be a powerful therapeutic agent against cancer were reported in… (More)
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