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Interleukin-27

Known as: IL-17D, Interleukin 27, Interleukin-27 [Chemical/Ingredient] 
A heterodimeric cytokine composed of the IL-27p28 and EBI3 subunits. It is produced primarily by antigen-presenting cells after stimulation by… 
National Institutes of Health

Related topics

Related topics

13 relations
IL17D geneIL27 geneIn BloodProcess of secretion

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IL27 protein, human

Papers overview

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Review
2015
Review
2015
Interleukin-27 in T Cell Immunity
Interleukin (IL)-27, a member of IL-12/IL-23 heterodimeric family of cytokines, has pleiotropic properties that can enhance or… 
Review
2014
Review
2014
Interleukin-17 in human inflammatory diseases
Human Th17 pro-inflammatory cells are currently defined as cells that produce IL-17A and F, tumor necrosis factor (TNF)-α, IL-6… 
Highly Cited
2009
Highly Cited
2009
IL-27 Blocks RORc Expression to Inhibit Lineage Commitment of Th17 Cells
IL-27 is secreted by APCs in response to inflammatory stimuli and exerts a proinflammatory Th1-enhancing activity but also has… 
Highly Cited
2009
Highly Cited
2009
Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon.
Infection of CD4(+) chemokine coreceptor(+) targets by HIV is aided and abetted by the proficiency of HIV in eliminating or… 
Highly Cited
2008
Highly Cited
2008
Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.
Review
2008
Review
2008
Regulation of immune responses by interleukin‐27
Summary: Cytokine‐mediated immunity plays a crucial role in the pathogenesis of various diseases including autoimmunity. Recently… 
Highly Cited
2008
Highly Cited
2008
Interleukin 27 attenuates collagen-induced arthritis
Objective: To investigate the potential role of interleukin (IL) 27 in rheumatoid arthritis (RA) by examining the expression of… 
Highly Cited
2006
Highly Cited
2006
Two-Sided Roles of IL-27: Induction of Th1 Differentiation on Naive CD4+ T Cells versus Suppression of Proinflammatory Cytokine Production Including IL-23-Induced IL-17 on Activated CD4+ T Cells…
Recent lines of evidence have demonstrated that IL-27, a newly identified IL-12-related cytokine, has two apparently conflicting… 
Highly Cited
2006
Highly Cited
2006
Antiangiogenic and Antitumor Activities of IL-271
IL-27 is a novel IL-6/IL-12 family cytokine playing an important role in the early regulation of Th1 responses. We have recently… 
Highly Cited
2004
Highly Cited
2004
IL-27 Signaling Compromises Control of Bacterial Growth in Mycobacteria-Infected Mice1
Resistance to tuberculosis (TB) is dependent on the induction of Ag-specific CD4 Th1 T cells capable of expressing IFN… 
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