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Interleukin-15

Known as: MGC9721, IL-15, IL15 
Interleukin-15 (162 aa, ~18 kDa) is encoded by the human IL15 gene. This protein plays a role in the regulation of both proliferation and activation… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
CD8(+) T cells undergo major metabolic changes upon activation, but how metabolism influences the establishment of long-lived… Expand
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Highly Cited
2010
Highly Cited
2010
T lymphocytes expressing a chimeric antigen receptor (CAR) targeting the CD19 antigen (CAR.19) may be of value for the therapy of… Expand
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Highly Cited
2009
Highly Cited
2009
Obesity is a risk factor for development of insulin resistance, type 2 diabetes, cardiovascular disease, osteoarthritis, and some… Expand
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Highly Cited
2007
Highly Cited
2007
The cytokine interleukin-15 (IL-15) has been demonstrated to have anabolic effects in cell culture systems. We tested the… Expand
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Highly Cited
2003
Highly Cited
2003
The genetic transfer of antigen receptors provides a means to rapidly generate autologous tumor-reactive T lymphocytes. However… Expand
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Highly Cited
2002
Highly Cited
2002
Cellular homeostasis requires a balance between cell production, cell survival, and cell death. Production of natural killer (NK… Expand
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Highly Cited
1997
Highly Cited
1997
Resting lymphocyte survival is dependent upon the expression of Bcl-2, yet the factors responsible for maintaining lymphocyte Bcl… Expand
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Highly Cited
1997
Highly Cited
1997
Tumor necrosis factor-α occupies a central role in rheumatoid arthritis (RA) pathogenesis. We now report that Interleukin-15 (IL… Expand
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Highly Cited
1996
Highly Cited
1996
Human natural killer (NK) cells are bone marrow (BM)-derived CD2+CD16+CD56+ large granular lymphocytes (LGL) that lack CD3 yet… Expand
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Highly Cited
1994
Highly Cited
1994
A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T… Expand
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