Interleukin-15

Known as: MGC9721, IL-15, IL15 
Interleukin-15 (162 aa, ~18 kDa) is encoded by the human IL15 gene. This protein plays a role in the regulation of both proliferation and activation… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2018
0204019942018

Related topics

Related topics

26 relations
Cell Proliferation Regulatory ProcessCytokine GeneCytokine Network PathwayCytokine Receptor Binding
(More)

Narrower (2)

IL-15-Fcgamma2a protein, humanRecombinant Interleukin-15

Broader (2)

InterleukinsLymphokines

Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
Interleukin-15
standards characteristics
physiological aspects
Interleukins
Intercellular Communication Process
Homo sapiens

Papers overview

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Highly Cited
2012
Highly Cited
2012
Mechanistic and structural insight into the functional dichotomy between interleukin-2 and interleukin-15
Interleukin 15 (IL-15) and IL-2 have distinct immunological functions even though both signal through the receptor subunit IL-2R… (More)
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Highly Cited
2009
Highly Cited
2009
Oversecretion of interleukin-15 from skeletal muscle reduces adiposity.
Obesity is a risk factor for development of insulin resistance, type 2 diabetes, cardiovascular disease, osteoarthritis, and some… (More)
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Highly Cited
2003
Highly Cited
2003
Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15
The genetic transfer of antigen receptors provides a means to rapidly generate autologous tumor-reactive T lymphocytes. However… (More)
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Highly Cited
2002
Highly Cited
2002
In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells.
Cellular homeostasis requires a balance between cell production, cell survival, and cell death. Production of natural killer (NK… (More)
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Highly Cited
1997
Highly Cited
1997
Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis
Tumor necrosis factor-α occupies a central role in rheumatoid arthritis (RA) pathogenesis. We now report that Interleukin-15 (IL… (More)
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Highly Cited
1997
Highly Cited
1997
A potential role for interleukin-15 in the regulation of human natural killer cell survival.
Resting lymphocyte survival is dependent upon the expression of Bcl-2, yet the factors responsible for maintaining lymphocyte Bcl… (More)
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Highly Cited
1995
Highly Cited
1995
Interleukin-15: a novel anabolic cytokine for skeletal muscle.
Interleukin-15 (IL-15) is a recently discovered growth factor which is highly expressed in skeletal muscle. In order to determine… (More)
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Highly Cited
1995
Highly Cited
1995
Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: comparison with interleukin-2.
Interleukin-15 is a new cytokine that stimulates the proliferation of T cells and other cells of the immune system. Some of the… (More)
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Highly Cited
1995
Highly Cited
1995
Chemoattraction of human blood T lymphocytes by interleukin-15
Recombinant interleukin (IL)-15, derived from a simian kidney epithelial cell line, is a chemoattractant for human blood T… (More)
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Highly Cited
1994
Highly Cited
1994
Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor.
A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T… (More)
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