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Interleukin-15

Known as: MGC9721, IL-15, IL15 
Interleukin-15 (162 aa, ~18 kDa) is encoded by the human IL15 gene. This protein plays a role in the regulation of both proliferation and activation… Expand
National Institutes of Health

Related topics

Related topics

26 relations
Cell Proliferation Regulatory ProcessCytokine GeneCytokine Network PathwayCytokine Receptor Binding
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Narrower (2)

IL-15-Fcgamma2a protein, humanRecombinant Interleukin-15

Broader (2)

InterleukinsLymphokines

Papers overview

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Highly Cited
2012
Highly Cited
2012
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development.
CD8(+) T cells undergo major metabolic changes upon activation, but how metabolism influences the establishment of long-lived… Expand
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Highly Cited
2010
Highly Cited
2010
Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety
T lymphocytes expressing a chimeric antigen receptor (CAR) targeting the CD19 antigen (CAR.19) may be of value for the therapy of… Expand
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Highly Cited
2009
Highly Cited
2009
Oversecretion of interleukin-15 from skeletal muscle reduces adiposity.
Obesity is a risk factor for development of insulin resistance, type 2 diabetes, cardiovascular disease, osteoarthritis, and some… Expand
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Highly Cited
2007
Highly Cited
2007
Expression of interleukin-15 in human skeletal muscle effect of exercise and muscle fibre type composition.
The cytokine interleukin-15 (IL-15) has been demonstrated to have anabolic effects in cell culture systems. We tested the… Expand
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Highly Cited
2003
Highly Cited
2003
Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15
The genetic transfer of antigen receptors provides a means to rapidly generate autologous tumor-reactive T lymphocytes. However… Expand
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Highly Cited
2002
Highly Cited
2002
In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells.
Cellular homeostasis requires a balance between cell production, cell survival, and cell death. Production of natural killer (NK… Expand
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Highly Cited
1997
Highly Cited
1997
A potential role for interleukin-15 in the regulation of human natural killer cell survival.
Resting lymphocyte survival is dependent upon the expression of Bcl-2, yet the factors responsible for maintaining lymphocyte Bcl… Expand
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Highly Cited
1997
Highly Cited
1997
Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis
Tumor necrosis factor-α occupies a central role in rheumatoid arthritis (RA) pathogenesis. We now report that Interleukin-15 (IL… Expand
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Highly Cited
1996
Highly Cited
1996
Role of interleukin-15 in the development of human CD56+ natural killer cells from CD34+ hematopoietic progenitor cells.
Human natural killer (NK) cells are bone marrow (BM)-derived CD2+CD16+CD56+ large granular lymphocytes (LGL) that lack CD3 yet… Expand
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Highly Cited
1994
Highly Cited
1994
Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor.
A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T… Expand
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