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Interleukin-15

Known as: MGC9721, IL-15, IL15 
Interleukin-15 (162 aa, ~18 kDa) is encoded by the human IL15 gene. This protein plays a role in the regulation of both proliferation and activation… 
National Institutes of Health

Related topics

Related topics

26 relations
Cell Proliferation Regulatory ProcessCytokine GeneCytokine Network PathwayCytokine Receptor Binding

Narrower (2)

IL-15-Fcgamma2a protein, humanRecombinant Interleukin-15

Broader (2)

InterleukinsLymphokines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Myxoma Virus Expressing a Fusion Protein of Interleukin-15 (IL15) and IL15 Receptor Alpha Has Enhanced Antitumor Activity
Myxoma virus, a rabbit poxvirus, can efficiently infect various types of mouse and human cancer cells. It is a strict rabbit… 
2012
2012
The use of an in vitro 3D melanoma model to predict in vivo plasmid transfection using electroporation.
2009
2009
High concentrations of interleukin 15 in breast milk are associated with protection against postnatal HIV transmission.
Given the central role that interleukin 15 (IL-15) plays in human immunodeficiency virus (HIV) immunity, we hypothesized that IL… 
Highly Cited
2006
Highly Cited
2006
Peripheral blood T lymphocytes from patients with early rheumatoid arthritis express RANKL and interleukin-15 on the cell surface and promote osteoclastogenesis in autologous monocytes.
OBJECTIVE To investigate the osteoclastogenic potential of T cells from the peripheral blood (PB) and synovial fluid (SF) of… 
Highly Cited
2006
Highly Cited
2006
Family based association analysis of the IL2 and IL15 genes in allergic disorders
Allergic diseases affect an increasing number of individuals and are a major global health problem. A substantial genetic… 
Highly Cited
2004
Highly Cited
2004
Differential Effects of Interleukin-7 and Interleukin-15 on NK Cell Anti-Human Immunodeficiency Virus Activity
ABSTRACT The ability of interleukin-7 (IL-7) and IL-15 to expand and/or augment effector cell functions may be of therapeutic… 
Highly Cited
2000
Highly Cited
2000
The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines.
Interleukin (IL)-2, a critical cytokine with indispensable functions in regulating lymphoid homeostasis, induces the activation… 
2000
2000
In vitro release of interleukin-15 by broncho-alveolar lavage cells and peripheral blood mononuclear cells from patients with different lung diseases.
IL-15 shares several biological activities with IL-2 and uses the b and g chain of the IL-2 receptor. In addition to its T-cell… 
2000
2000
Restoration of cytotoxic T lymphocyte function in malignant pleural effusion: interleukin-15 vs. interleukin-2.
The present study attempts to define the role of interleukin-15 (IL-15), as compared with IL-2, in generating cytotoxic T… 
Highly Cited
1998
Highly Cited
1998
Interleukin-15 May Be Responsible for Early Activation of Intestinal Intraepithelial Lymphocytes after Oral Infection with Listeria monocytogenes in Rats
ABSTRACT Exogenous interleukin-15 (IL-15) stimulates intestinal intraepithelial lymphocytes (i-IEL) from mice to proliferate and… 
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