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Recombinant Interleukin-15

Known as: rIL15, rhIL-15, IL15 
A recombinant agent that is chemically identical or similar to the endogenous form of the human cytokine interleukin-15 (IL-15) with immunomodulating… Expand
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
PURPOSE Interleukin-15 (IL-15) has significant potential in cancer immunotherapy as an activator of antitumor CD8 T and natural… Expand
Highly Cited
2015
Highly Cited
2015
IL15 stimulates T-cell and NK-cell responses, but not Tregs. The antitumor efficacy, biodistribution, and toxicity of an IL15… Expand
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Review
2015
Review
2015
Preclinical models revealed that the immune system can mediate rejection of established tumors, but direct evidence in humans has… Expand
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Highly Cited
2011
Highly Cited
2011
IL-15 uses the heterotrimeric receptor IL-2/IL-15Rβ and the γ chain shared with IL-2 and the cytokine-specific IL-15Rα. Although… Expand
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2011
2011
Contrary to the reduction of depressive-like behavior observed in several strains of cytokine receptor knockout mice, mice… Expand
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Review
2010
Review
2010
Cytokines that signal through the common-gamma chain are potent growth factors for T cells and natural killer cells. Interleukin… Expand
Highly Cited
2005
Highly Cited
2005
Current models of T cell memory implicate a critical role for IL-7 in the effector-to-memory transition, raising the possibility… Expand
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Highly Cited
2003
Highly Cited
2003
Interleukin 15 (IL-15) is a potent stimulator of proliferation and an inhibitor of apoptosis in lymphocytes. We attempted to… Expand
Highly Cited
2000
Highly Cited
2000
Cytokines are important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. Here… Expand
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Highly Cited
2000
Highly Cited
2000
In eukaryotic cells, protein disulfide isomerase (PDI) found in the endoplasmic reticulum (ER) catalyzes disulfide bond exchange… Expand