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Interferon Regulatory Factor 4

Known as: LSIRF protein, human, IRF-4, hLSIRF protein, human 
Interferon regulatory factor 4 (451 aa, ~52 kDa) is encoded by the human IRF4 gene. This protein is involved in the mediation of both T-cell… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper 2 (Th2) and Th17 cells. Herein, we report that… Expand
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Highly Cited
2010
Highly Cited
2010
In mouse, a subset of dendritic cells (DCs) known as CD8α+ DCs has emerged as an important player in the regulation of T cell… Expand
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Highly Cited
2009
Highly Cited
2009
In the course of infection or autoimmunity, particular transcription factors orchestrate the differentiation of TH1, TH2 or TH17… Expand
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Highly Cited
2009
Highly Cited
2009
T helper (Th) 17 cells have been recently discovered in both mouse and human. Here we show that interleukin-1 (IL-1) signaling on… Expand
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Highly Cited
2007
Highly Cited
2007
Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper type 2 cells. Here we show that IRF4 is also… Expand
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Highly Cited
2006
Highly Cited
2006
Molecular mechanisms underlying the coordination of isotype switching with plasma cell differentiation are poorly understood. We… Expand
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Highly Cited
2004
Highly Cited
2004
Diffuse large B-cell lymphoma (DLBCL) can be divided into prognostically important subgroups with germinal center B-cell-like… Expand
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Highly Cited
2004
Highly Cited
2004
IFN regulatory factors (IRFs) are a family of transcription factors that play an essential role in the homeostasis and function… Expand
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Highly Cited
2002
Highly Cited
2002
Proteins of the nuclear factor of activated T cells (NFAT) family of transcription factors are critical for lymphocyte activation… Expand
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Highly Cited
2002
Highly Cited
2002
Certain IFN regulatory factor (IRF) transcription factors indirectly influence T helper (Th) cell differentiation by regulating… Expand
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