Interferon Regulatory Factor 4

Known as: LSIRF protein, human, IRF-4, hLSIRF protein, human 
Interferon regulatory factor 4 (451 aa, ~52 kDa) is encoded by the human IRF4 gene. This protein is involved in the mediation of both T-cell… (More)
National Institutes of Health

Related topics

Related topics

11 relations
Cell Differentiation processCell NucleusDNA-Binding ProteinsGenes, Regulator
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Broader (2)

IRF4 wt Alleleinterferon regulatory factor-4

Papers overview

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Highly Cited
2013
Highly Cited
2013
Interferon regulatory factor 4 sustains CD8(+) T cell expansion and effector differentiation.
Upon infection, CD8(+) T cells undergo a stepwise process of early activation, expansion, and differentiation into effector cells… (More)
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Highly Cited
2010
Highly Cited
2010
Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells.
Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper 2 (Th2) and Th17 cells. Herein, we report that… (More)
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Highly Cited
2009
Highly Cited
2009
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses
In the course of infection or autoimmunity, particular transcription factors orchestrate the differentiation of TH1, TH2 or TH17… (More)
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Highly Cited
2007
Highly Cited
2007
The development of inflammatory TH-17 cells requires interferon-regulatory factor 4
Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper type 2 cells. Here we show that IRF4 is also… (More)
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Highly Cited
2006
Highly Cited
2006
Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation.
Molecular mechanisms underlying the coordination of isotype switching with plasma cell differentiation are poorly understood. We… (More)
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Highly Cited
2005
Highly Cited
2005
IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity.
Dendritic cells (DCs) are bone marrow (BM)-derived APCs central to both innate and adaptive immunity. DCs are a heterogeneous… (More)
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Highly Cited
2004
Highly Cited
2004
Critical roles of interferon regulatory factor 4 in CD11bhighCD8alpha- dendritic cell development.
IFN regulatory factors (IRFs) are a family of transcription factors that play an essential role in the homeostasis and function… (More)
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Highly Cited
2002
Highly Cited
2002
Interferon Regulatory Factor 4 (IRF4) Interacts with NFATc2 to Modulate Interleukin 4 Gene Expression
Proteins of the nuclear factor of activated T cells (NFAT) family of transcription factors are critical for lymphocyte activation… (More)
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Highly Cited
2002
Highly Cited
2002
Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4.
Certain IFN regulatory factor (IRF) transcription factors indirectly influence T helper (Th) cell differentiation by regulating… (More)
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Highly Cited
2000
Highly Cited
2000
Rel Induces Interferon Regulatory Factor 4 (IRF-4) Expression in Lymphocytes
In lymphocytes, the Rel transcription factor is essential in establishing a pattern of gene expression that promotes cell… (More)
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