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Interferon Regulatory Factor 4

Known as: LSIRF protein, human, IRF-4, hLSIRF protein, human 
Interferon regulatory factor 4 (451 aa, ~52 kDa) is encoded by the human IRF4 gene. This protein is involved in the mediation of both T-cell… Expand
National Institutes of Health

Related topics

Related topics

11 relations
Cell Differentiation processCell NucleusDNA-Binding ProteinsGenes, Regulator
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Broader (2)

IRF4 wt Alleleinterferon regulatory factor-4

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells.
Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper 2 (Th2) and Th17 cells. Herein, we report that… Expand
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Highly Cited
2010
Highly Cited
2010
Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cells
In mouse, a subset of dendritic cells (DCs) known as CD8α+ DCs has emerged as an important player in the regulation of T cell… Expand
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Highly Cited
2009
Highly Cited
2009
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses
In the course of infection or autoimmunity, particular transcription factors orchestrate the differentiation of TH1, TH2 or TH17… Expand
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Highly Cited
2009
Highly Cited
2009
Critical regulation of early Th17 cell differentiation by interleukin-1 signaling.
T helper (Th) 17 cells have been recently discovered in both mouse and human. Here we show that interleukin-1 (IL-1) signaling on… Expand
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Highly Cited
2007
Highly Cited
2007
The development of inflammatory TH-17 cells requires interferon-regulatory factor 4
Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper type 2 cells. Here we show that IRF4 is also… Expand
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Highly Cited
2006
Highly Cited
2006
Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation.
Molecular mechanisms underlying the coordination of isotype switching with plasma cell differentiation are poorly understood. We… Expand
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Highly Cited
2004
Highly Cited
2004
Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray.
Diffuse large B-cell lymphoma (DLBCL) can be divided into prognostically important subgroups with germinal center B-cell-like… Expand
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Highly Cited
2004
Highly Cited
2004
Critical roles of interferon regulatory factor 4 in CD11bhighCD8α– dendritic cell development
IFN regulatory factors (IRFs) are a family of transcription factors that play an essential role in the homeostasis and function… Expand
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Highly Cited
2002
Highly Cited
2002
Interferon Regulatory Factor 4 (IRF4) Interacts with NFATc2 to Modulate Interleukin 4 Gene Expression
Proteins of the nuclear factor of activated T cells (NFAT) family of transcription factors are critical for lymphocyte activation… Expand
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Highly Cited
2002
Highly Cited
2002
Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4
Certain IFN regulatory factor (IRF) transcription factors indirectly influence T helper (Th) cell differentiation by regulating… Expand
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