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Integrin beta3

Known as: GPIIIa, beta 3 integrin, beta3 Integrin 
An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing… 
National Institutes of Health

Related topics

Related topics

11 relations
Cells.CD61:NCnc:Pt:Bld:QnITGB3 geneIn BloodIntegrin alphaVbeta3

Narrower (3)

ITGB3 protein, humanIntegrin beta3Aglycoprotein IIIa-derived peptide (217-231)

Broader (1)

Platelet Membrane Glycoproteins

Papers overview

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Highly Cited
2004
Highly Cited
2004
Human marrow megakaryocyte differentiation: multiparameter correlative analysis identifies von Willebrand factor as a sensitive and distinctive marker for early (2N and 4N) megakaryocytes.
Human megakaryocyte differentiation and maturation were studied in fresh marrow aspirates by using multiparameter flow cytometric… 
Highly Cited
2004
Highly Cited
2004
Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides.
Although integrin alpha subunit I domains exist in multiple conformations, it is controversial whether integrin beta subunit I… 
Review
1997
Review
1997
Integrin function in osteoclasts.
Integrins are a large family of heteromeric cell surface receptors composed of non-covalently bound alpha and beta subunits which… 
Highly Cited
1996
Highly Cited
1996
Beta3 integrin expression in melanoma predicts subsequent metastasis.
Previous studies have suggested that differential expression and/or activation of integrins facilitates metastatic progression in… 
Highly Cited
1996
Highly Cited
1996
Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin
Thrombopoietin (TPO) is the major regulator of growth and differentiation of megakaryocytes. To identify functionally important… 
Highly Cited
1995
Highly Cited
1995
Molecular interactions between fibronectin and integrins during mouse blastocyst outgrowth
To investigate the mechanism of trophoblast adhesion to fibronectin, we cultured blastocysts in serum‐free medium on proteolytic… 
Highly Cited
1994
Highly Cited
1994
Phenotype analysis of hematopoietic CD34+ cell populations derived from human umbilical cord blood using flow cytometry and cDNA-polymerase chain reaction.
A strategy to phenotype rare populations of hematopoietic cells expressing the cell-surface marker CD34 was studied. The… 
Highly Cited
1994
Highly Cited
1994
A point mutation leads to an unpaired cysteine residue and a molecular weight polymorphism of a functional platelet beta 3 integrin subunit. The Sra alloantigen system of GPIIIa.
Highly Cited
1991
Highly Cited
1991
Involvement of platelet glycoprotein IIb-IIIa (alpha IIb-beta 3 integrin) in thrombin-induced synthesis of phosphatidylinositol 3',4'-bisphosphate.
Highly Cited
1989
Highly Cited
1989
Biosynthesis and assembly of platelet GPIIb-IIIa in human megakaryocytes: evidence that assembly between pro-GPIIb and GPIIIa is a prerequisite for expression of the complex on the cell surface.
The platelet membrane glycoproteins GPIIb and GPIIIa form a calcium-dependent heterodimer that functions as a receptor for… 
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