FAQ

ITGB3 protein, human

Known as: GPIIIa, Platelet Membrane Glycoprotein IIIa, CD61 Antigen 
Integrin beta-3 (788 aa, ~87 kDa) is encoded by the human ITGB3 gene. This protein plays a role in cell-matrix adhesion, integrin signaling and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1983-2017
0102019832017

Related topics

Related topics

17 relations
Blood coagulationCell AdhesionCell Adhesion Molecule GeneClusters of differentiation
(More)

Broader (1)

Integrin beta3

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
ITGB3 protein, human
Plasma membrane
Cell Adhesion
Wound Healing
Integrins
Ligand Binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3.
MicroRNAs play an important regulatory role in carcinogenesis and cancer metastasis. Different members of let-7 family have been… (More)
Is this relevant?
2010
2010
The GPIIIA PlA2 polymorphism is associated with an increased risk of cardiovascular adverse events
BACKGROUND The clinical impact of PlA2 polymorphism has been investigated in several diseases, but the definition of its specific… (More)
  • table 1
  • table 2
  • figure 1
  • table 3
  • table 4
Is this relevant?
2010
2010
Correlation between immature platelet fraction and reticulated platelets. Usefulness in the etiology diagnosis of thrombocytopenia.
BACKGROUND Reticulated platelets (RP) are a surrogate marker for megakaryocytic activity, but the limitation of this… (More)
  • table 1
  • figure 1
  • figure 2
Is this relevant?
2007
2007
Mapping helper T-cell epitopes on platelet membrane glycoprotein IIIa in chronic autoimmune thrombocytopenic purpura.
Chronic autoimmune thrombocytopenic purpura (AITP) is associated with autoantibodies specific for platelet membrane components… (More)
  • table 1
  • table 2
  • table 3
  • table 4
  • table 4
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels
Autism is a neurodevelopmental disorder of unclear etiology. The consistent finding of platelet hyperserotonemia in a proportion… (More)
  • table 1
  • table 2
  • table 3
  • figure 1
  • table 4
Is this relevant?
2006
2006
ITGB3 shows genetic and expression interaction with SLC6A4
Autism affects more males than females and is associated with disturbances of the serotonin system. The integrin β3 (ITGB3) and… (More)
  • table 1
  • figure 1
  • figure 2
  • table 2
Is this relevant?
2005
2005
Pravastatin reduces fibrinogen receptor gpIIIa on platelet-derived microparticles in patients with type 2 diabetes.
 
Is this relevant?
2005
2005
Galectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein.
BACKGROUND Galectin-3 is expressed in the synovial tissue of patients with rheumatoid arthritis (RA), particularly at sites of… (More)
Is this relevant?
2004
2004
Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin
Serotonin has been implicated in common disorders involving the central nervous, gastrointestinal, cardiovascular, and pulmonary… (More)
  • table 1
  • figure 1
  • figure 2
Is this relevant?
1998
1998
Polymorphism of platelet membrane glycoprotein IIIa: human platelet antigen 1b (HPA-1b/PlA2) is an inherited risk factor for premature myocardial infarction in coronary artery disease.
Conflicting results of an association between the human platelet antigen 1b (HPA-1b or PlA2) allele and the risk of myocardial… (More)
Is this relevant?