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ITGB3 protein, human
Known as:
GPIIIa
, Platelet Membrane Glycoprotein IIIa
, CD61 Antigen
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Integrin beta-3 (788 aa, ~87 kDa) is encoded by the human ITGB3 gene. This protein plays a role in cell-matrix adhesion, integrin signaling and…
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National Institutes of Health
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Related topics
Related topics
17 relations
Blood coagulation
Cell Adhesion
Clusters of differentiation
Focal adhesion pathway
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Broader (1)
Integrin beta3
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells
A. Misra
,
Zhonghui Feng
,
+9 authors
D. Greif
Nature Communications
2018
Corpus ID: 44082462
Smooth muscle cells (SMCs) play a key role in atherogenesis. However, mechanisms regulating expansion and fate of pre-existing…
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Highly Cited
2013
Highly Cited
2013
In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling.
P. Miller
,
F. Al-Shahrour
,
+25 authors
B. Ebert
Cancer Cell
2013
Corpus ID: 6408457
Highly Cited
2011
Highly Cited
2011
Proteomics Identification of ITGB3 as a Key Regulator in Reactive Oxygen Species-induced Migration and Invasion of Colorectal Cancer Cells*
Yunlong Lei
,
Kai Huang
,
+14 authors
Yuquan Wei
Molecular & Cellular Proteomics
2011
Corpus ID: 20937867
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and second in females worldwide. Unfortunately 40–50…
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Highly Cited
2010
Highly Cited
2010
The GPIIIA PlA2 polymorphism is associated with an increased risk of cardiovascular adverse events
G. Galasso
,
G. Santulli
,
+7 authors
M. Chiariello
BMC Cardiovascular Disorders
2010
Corpus ID: 10637986
BackgroundThe clinical impact of PlA2 polymorphism has been investigated in several diseases, but the definition of its specific…
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Highly Cited
2009
Highly Cited
2009
Experimental Murine Endometriosis Induces DNA Methylation and Altered Gene Expression in Eutopic Endometrium1
B. Lee
,
Hongling Du
,
H. Taylor
Biology of Reproduction
2009
Corpus ID: 205354772
Abstract The eutopic endometrium in women with endometriosis demonstrates diminished endometrial receptivity and altered gene…
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Highly Cited
2008
Highly Cited
2008
The Foxc2 Transcription Factor Regulates Angiogenesis via Induction of Integrin β3 Expression*
H. Hayashi
,
H. Sano
,
Seungwoon Seo
,
T. Kume
Journal of Biological Chemistry
2008
Corpus ID: 25071051
Forkhead transcription factor Foxc2 is an essential regulator of the cardiovascular system in development and disease. However…
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Highly Cited
2006
Highly Cited
2006
Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels
A. Coutinho
,
I. Sousa
,
+9 authors
A. Vicente
Human Genetics
2006
Corpus ID: 3294316
Autism is a neurodevelopmental disorder of unclear etiology. The consistent finding of platelet hyperserotonemia in a proportion…
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Highly Cited
2004
Highly Cited
2004
Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin
L. Weiss
,
J. Veenstra-VanderWeele
,
+7 authors
M. Abney
European Journal of Human Genetics
2004
Corpus ID: 8424153
Serotonin has been implicated in common disorders involving the central nervous, gastrointestinal, cardiovascular, and pulmonary…
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Highly Cited
1998
Highly Cited
1998
Polymorphism of platelet membrane glycoprotein IIIa: human platelet antigen 1b (HPA-1b/PlA2) is an inherited risk factor for premature myocardial infarction in coronary artery disease.
R. Zotz
,
B. Winkelmann
,
+4 authors
R. Scharf
Thrombosis and Haemostasis
1998
Corpus ID: 11360769
Conflicting results of an association between the human platelet antigen 1b (HPA-1b or PlA2) allele and the risk of myocardial…
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Highly Cited
1992
Highly Cited
1992
An amino acid polymorphism within the RGD binding domain of platelet membrane glycoprotein IIIa is responsible for the formation of the Pena/Penb alloantigen system.
R. Wang
,
K. Furihata
,
J. Mcfarland
,
K. Friedman
,
R. Aster
,
P. Newman
Journal of Clinical Investigation
1992
Corpus ID: 18858253
The human Pena/Penb alloantigen system represents a naturally occurring polymorphism of human platelet membrane glycoprotein (GP…
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