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Integrin alpha4

Known as: Antigens, CD49d, CD49d Antigens, CD49 Antigen-Like Family Member D 
An integrin alpha subunit that is unique in that it does not contain an I domain, and its proteolytic cleavage site is near the middle of the… 
National Institutes of Health

Related topics

Related topics

24 relations
Blood coagulationCell AdhesionCell-Cell Adhesion ProcessCell-Matrix Junction

Broader (3)

CD AntigensIntegrinsLymphocyte Homing Receptors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Bortezomib overcomes cell adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma
Multiple myeloma (MM) is incurable, mainly because of cell adhesion-mediated drug resistance (CAM-DR). In this study, we… 
Highly Cited
2004
Highly Cited
2004
Anti-alpha4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis.
Supporting roles of stromal cells in preferential colonization of myeloma cells in bone marrow and development of associated… 
Highly Cited
2004
Highly Cited
2004
CC Chemokine Ligands 25 and 28 Play Essential Roles in Intestinal Extravasation of IgA Antibody-Secreting Cells1
CCL25 (also known as thymus-expressed chemokine) and CCL28 (also known as mucosae-associated epithelial chemokine) play important… 
Highly Cited
2003
Highly Cited
2003
Deletion of α4 Integrins from Adult Hematopoietic Cells Reveals Roles in Homeostasis, Regeneration, and Homing
ABSTRACT We have explored the functional implications of inducible α4 integrin deletion during adult hematopoiesis by generating… 
Highly Cited
2003
Highly Cited
2003
Lymphocyte Homing to Bronchus-associated Lymphoid Tissue (BALT) Is Mediated by L-selectin/PNAd, α4β1 Integrin/VCAM-1, and LFA-1 Adhesion Pathways
Bronchus-associated lymphoid tissue (BALT) participates in airway immune responses. However, little is known about the lymphocyte… 
Highly Cited
2002
Highly Cited
2002
The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes.
Malignant lymphocyte migration into lymph nodes is an important aspect of chronic lymphocytic leukemia (CLL), yet little is known… 
Highly Cited
1992
Highly Cited
1992
A monoclonal antibody to beta 1 integrin (CD29) stimulates VLA- dependent adherence of leukocytes to human umbilical vein endothelial cells and matrix components
The leukocyte beta 1 integrin receptor very late activation antigen-4 (VLA-4) (alpha 4 beta 1, CD49d/CD29) binds to vascular cell… 
Highly Cited
1992
Highly Cited
1992
Flow cytometric assessment of human T-cell differentiation in thymus and bone marrow.
Using multidimensional flow cytometry we have defined and quantified the human T-cell differentiation pathway, focusing on those… 
Highly Cited
1991
Highly Cited
1991
Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis.
The VLA-4 (CD49d/CD29) integrin is a cell surface receptor involved in the interaction of lymphoid cells with both extracellular… 
Highly Cited
1991
Highly Cited
1991
Human eosinophil, but not neutrophil, adherence to IL-1-stimulated human umbilical vascular endothelial cells is alpha 4 beta 1 (very late antigen-4) dependent.
Eosinophils, through their ability to generate an array of potent mediators, are thought to be the major effector cells in a… 
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