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Integrin Beta-2, human

Known as: Lymphocyte Function-Associated Cell Surface Adhesion Glycoprotein, Beta 2 Integrin Chain, ITGB2 
Integrin beta-2 (769 aa, ~85 kDa) is encoded by the human ITGB2 gene. This protein is involved in complement C3 binding, leukocyte adhesion, and… 
National Institutes of Health

Related topics

Related topics

12 relations

Broader (1)

CD18 Antigens
Cell AdhesionCell-Cell Adhesion ProcessChemotaxisClusters of differentiation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
The expanding functional diversity of plasma cells in immunity and inflammation
The generation and function of plasma cells have been well recognized as the central events in humoral immunity. In particular… 
Highly Cited
2018
Highly Cited
2018
Critical role of integrin CD11c in splenic dendritic cell capture of missing-self CD47 cells to induce adaptive immunity
Significance The cell surface protein CD47 functions as a self-recognition molecule on mammalian cells, sending a negative “don’t… 
Highly Cited
2018
Highly Cited
2018
LncRNA ITGB2-AS1 Could Promote the Migration and Invasion of Breast Cancer Cells through Up-Regulating ITGB2
In the previous study, we screened a novel lncRNA-ITGB2-AS1, which was down-regulated by bone morphogenetic protein 9 (BMP9) in… 
2015
2015
Cyclic stretch induced gene expression of extracellular matrix and adhesion molecules in human periodontal ligament cells.
2014
2014
Cellular Adhesion Gene SELP Is Associated with Rheumatoid Arthritis and Displays Differential Allelic Expression
In rheumatoid arthritis (RA), a key event is infiltration of inflammatory immune cells into the synovial lining, possibly… 
2014
2014
CD18 (ITGB2) expression in chronic lymphocytic leukaemia is regulated by DNA methylation-dependent and -independent mechanisms
The integrin lymphocyte function-associated antigen 1 (LFA-1; CD11A/CD18; ITGAL/ITGB2), is a key regulator of lymphocyte… 
Review
2013
Review
2013
Nutritionally Mediated Oxidative Stress and Inflammation
There are many sources of nutritionally mediated oxidative stress that trigger inflammatory cascades along short and long time… 
Highly Cited
2012
Highly Cited
2012
YAP promotes breast cell proliferation and survival partially through stabilizing the KLF5 transcription factor.
2011
2011
Panax notoginseng saponins inhibit Zymosan A induced atherosclerosis by suppressing integrin expression, FAK activation and NF-κB translocation.
Highly Cited
1999
Highly Cited
1999
A missense mutation in the beta-2 integrin gene (ITGB2) causes canine leukocyte adhesion deficiency.
Canine leukocyte adhesion deficiency (CLAD) is a fatal immunodeficiency disease found in Irish setters. The clinical… 
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