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A chemokine-driven positive feedback loop organizes lymphoid follicles
TLDR
It is established that B-lymphocyte chemoattractant (BLC/BCA1) and its receptor, CXCR5, are needed for B-cell homing to follicles in lymph nodes as well as in spleen, and that BLC is required for the development of most lymph nodes and Peyer's patches.
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Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
TLDR
It is suggested that lymph nodes and T zone fibroblastic reticular cells have a key function in naive CD4+ and CD8+ T cell homeostasis by providing a limited reservoir of survival factors.
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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
TLDR
It is established that S1P1 is essential for lymphocyte recirculation and that it regulates egress from both thymus and peripheral lymphoid organs.
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Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5
TLDR
It is confirmed that GC organization depends on sorting of centroblasts by CXCR4 into the dark zone, and that deficiency in CXCL13 was associated with aberrant light zone localization.
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A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo
TLDR
A protein with the hallmarks of a chemokine, designated CXCL16, that is made by dendritic cells in lymphoid organ T cell zones and by cells in the splenic red pulp is described, indicating roles in thymocyte development and effector T cell trafficking.
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A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes.
TLDR
SLC is the first chemokine demonstrated to have the characteristics required to mediate homing of lymphocytes to secondary lymphoid organs and the expression of SLC in lymphatic endothelium suggests that the migration of lymphocyte from tissues into efferent lymphatics may be an active process mediated by this molecule.
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Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs.
  • J. Cyster
  • Biology, Medicine
    Annual review of immunology
  • 2005
TLDR
The steps associated with the initiation of adaptive immune responses in secondary lymphoid organs are reviewed, highlighting the roles of chemokines and S1P.
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Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients
TLDR
It is concluded that lymphocyte egress is mediated by S 1P gradients that are established by S1P lyase activity and that the lyase may represent a novel immunosuppressant drug target.
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Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation1
TLDR
It is suggested that development and/or maintenance of a PD-1high follicular Th cell subset is dependent on appropriate interaction with GC B cells, and this study finds that transgenic CXCR5 overexpression is not sufficient to promote follicular entry of naive T cells unless the counterbalancing influence of CCR7 ligands is removed.
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CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.
TLDR
It is shown that treatment with the IFN-alpha/beta inducer polyinosine polycytidylic acid inhibited egress by a mechanism that was partly lymphocyte-intrinsic and that CD69 forms a complex with and negatively regulates S1P1 and that it functions downstream ofIFN- alpha/beta, and possibly other activating stimuli, to promote lymphocyte retention in lymphoid organs.
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