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Insulin Resistance
Known as:
Insulin Resistance [Disease/Finding]
, Resistance, Insulin
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent…
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National Institutes of Health
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Related topics
Related topics
17 relations
ANDIBULAR HYPOPLASIA, DEAFNESS, PROGEROID FEATURES, AND LIPODYSTROPHY SYNDROME
Diabetes Mellitus
Donohue Syndrome
Insulin Resistance Measurement
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Narrower (2)
Diabetes Mellitus, Insulin-Resistant, with Acanthosis Nigricans
HAIR-AN syndrome
Broader (2)
Drug resistance
insulin sensitivity/resistance
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Patrice D Cani
,
J. Amar
,
+19 authors
R. Burcelin
Diabetes
2007
Corpus ID: 27663360
Diabetes and obesity are two metabolic diseases characterized by insulin resistance and a low-grade inflammation. Seeking an…
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Review
2006
Review
2006
Mechanisms linking obesity to insulin resistance and type 2 diabetes
S. Kahn
,
R. Hull
,
K. Utzschneider
Nature
2006
Corpus ID: 120626
Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes. In obese individuals, adipose…
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Review
2006
Review
2006
Inflammation and insulin resistance.
S. Shoelson
,
Jongsoon Lee
,
A. Goldfine
The Journal of clinical investigation
2006
Corpus ID: 10624172
Over a hundred years ago, high doses of salicylates were shown to lower glucose levels in diabetic patients. This should have…
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Highly Cited
2004
Highly Cited
2004
Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
D. Matthews
,
J. Hosker
,
A. Rudenski
,
B. Naylor
,
D. Treacher
,
R. Turner
Diabetologia
2004
Corpus ID: 24872571
SummaryThe steady-state basal plasma glucose and insulin concentrations are determined by their interaction in a feedback loop. A…
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Highly Cited
2003
Highly Cited
2003
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
Haiyan Xu
,
Glenn Barnes
,
+8 authors
Hong Chen
The Journal of clinical investigation
2003
Corpus ID: 17236229
Insulin resistance arises from the inability of insulin to act normally in regulating nutrient metabolism in peripheral tissues…
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Highly Cited
2001
Highly Cited
2001
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
T. Yamauchi
,
J. Kamon
,
+22 authors
T. Kadowaki
Nature Medicine
2001
Corpus ID: 31308235
Adiponectin is an adipocyte-derived hormone. Recent genome-wide scans have mapped a susceptibility locus for type 2 diabetes and…
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Highly Cited
1995
Highly Cited
1995
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
G. Hotamisligil
,
P. Arner
,
J. F. Caro
,
R. Atkinson
,
B. Spiegelman
The Journal of clinical investigation
1995
Corpus ID: 14488702
Obesity is frequently associated with insulin resistance and abnormal glucose homeostasis. Recent studies in animal models have…
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Highly Cited
1993
Highly Cited
1993
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.
G. Hotamisligil
,
N. Shargill
,
B. Spiegelman
Science
1993
Corpus ID: 44726336
Tumor necrosis factor-alpha (TNF-alpha) has been shown to have certain catabolic effects on fat cells and whole animals. An…
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Review
1991
Review
1991
Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease
R. DeFronzo
,
E. Ferrannini
Diabetes Care
1991
Corpus ID: 41910286
Diabetes mellitus is commonly associated with systolic/diastolic hypertension, and a wealth of epidemiological data suggest that…
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Highly Cited
1988
Highly Cited
1988
Role of Insulin Resistance in Human Disease
G. Reaven
Diabetes
1988
Corpus ID: 73001621
Resistance to insulin-stimulated glucose uptake is present in the majority of patients with impaired glucose tolerance (IGT) or…
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