Imidazole

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1972-2017
0102019722017

Papers overview

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2013
2013
Many cancer therapeutics target DNA and exert cytotoxicity through the induction of DNA damage and inhibition of transcription… (More)
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2010
2010
Despite high specificity and potency, small interfering RNA (siRNA)-based therapeutics have been limited by their poor… (More)
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2009
2009
Pyrrole-imidazole polyamide can be combined in antiparallel side-by-side dimeric complexes along the minor groove of DNA in a… (More)
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2005
2005
Since H3 receptor (H3R) antagonists/inverse agonists can improve cognitive function in animal models, they may have the potential… (More)
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2004
2004
The overexpression of P-glycoprotein (P-gp) by tumor cells results in multidrug resistance (MDR) to structurally unrelated… (More)
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Highly Cited
2003
Highly Cited
2003
Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection… (More)
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Highly Cited
1999
Highly Cited
1999
Ribozymes use a number of the same catalytic strategies as protein enzymes. However, general base catalysis by a ribozyme has not… (More)
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Highly Cited
1990
Highly Cited
1990
The repair of 2,6-diamino-4-hydroxy-5-N-methyl-formamidopyrimidine (Fapy) residues in DNA is performed by a Fapy-DNA glycosylase… (More)
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1979
1979
Double-stranded DNA containing 7-methylguanine residues whose imidazole rings have been opened, i.e. 2,6-diamino-4-hydroxy-5-N… (More)
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1977
1977
Imidazole inhibits the enzymic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes (IC50: 22… (More)
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