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Imexon

A 2-cyanoaziridine derivative with antitumor activity in multiple myeloma. Although its mechanism of action is not clearly known, imexon may induce… 
National Institutes of Health

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Amplimexon
Free Radical ProcessPositive Regulation of ApoptosisSignal Induction

Papers overview

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2012
2012
Imexon Induces an Oxidative Endoplasmic Reticulum Stress Response in Pancreatic Cancer Cells
Oxidative protein folding in the endoplasmic reticulum (ER) requires strict regulation of redox homeostasis. Disruption of the… 
2006
2006
Correlates of imexon sensitivity in human multiple myeloma cell lines
Imexon (NSC-714597) is an aziridine-containing imminopyrolidone in Phase I clinical trials. The current studies compared… 
2005
2005
Pharmaceutical development of a lyophilised dosage form for the investigational anticancer agent Imexon using dimethyl sulfoxide as solubilising and stabilising agent.
Imexon is a member of the class of 2-cyanoaziridine derivatives, which have been of interest as immunomodulators and anticancer… 
Highly Cited
2004
Highly Cited
2004
Imexon-Induced Apoptosis in Multiple Myeloma Tumor Cells Is Caspase-8 Dependent
Purpose: Imexon is a 2-cyanoaziridine agent that has been shown to inhibit growth of chemotherapy-sensitive myeloma cells through… 
Highly Cited
2004
Highly Cited
2004
Chemical basis for the biological activity of imexon and related cyanoaziridines.
Chemical aspects of mode of action of imexon and related cyanoaziridines were studied. These compounds do not alkylate DNA nor… 
Highly Cited
2003
Highly Cited
2003
Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis.
Peroxiredoxin-3 (Prdx3) is a mitochondrial member of the antioxidant family of thioredoxin peroxidases that uses mitochondrial… 
Highly Cited
2003
Highly Cited
2003
Antitumour potential of a polysaccharide‐rich substance from the fruit juice of Morinda citrifolia (Noni) on sarcoma 180 ascites tumour in mice
An immunomodulatory polysaccharide‐rich substance (Noni‐ppt) from the fruit juice of Morinda citrifolia has been found to possess… 
2002
2002
Molecular and cellular characterization of imexon-resistant RPMI8226/I myeloma cells.
Imexon is an aziridine-containing iminopyrrolidone with selective growth-inhibitory potency for multiple myeloma. Our previous… 
2002
2002
Imexon activates an intrinsic apoptosis pathway in RPMI8226 myeloma cells
Imexon is a new antitumor agent with high activity in multiple myeloma. This drug induces apoptosis, oxidative stress and… 
Highly Cited
2001
Highly Cited
2001
Induction of mitochondrial changes in myeloma cells by imexon.
Imexon is a cyanoaziridine derivative that has antitumor activity in multiple myeloma. Previous studies have shown that imexon… 
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