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Imexon

A 2-cyanoaziridine derivative with antitumor activity in multiple myeloma. Although its mechanism of action is not clearly known, imexon may induce… 
National Institutes of Health

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Amplimexon
Free Radical ProcessPositive Regulation of ApoptosisSignal Induction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Magnetic Resonance Imaging Identifies Differential Response to Pro-Oxidant Chemotherapy in a Xenograft Model1
2006
2006
Correlates of imexon sensitivity in human multiple myeloma cell lines
Imexon (NSC-714597) is an aziridine-containing imminopyrolidone in Phase I clinical trials. The current studies compared… 
2006
2006
Preclinical antitumor activity, pharmacokinetics and pharmacodynamics of imexon in mice
Imexon, a novel pro-oxidant, thiol-binding agent, is currently in phase I/II clinical trials in patients with advanced solid… 
Highly Cited
2004
Highly Cited
2004
Chemical basis for the biological activity of imexon and related cyanoaziridines.
Chemical aspects of mode of action of imexon and related cyanoaziridines were studied. These compounds do not alkylate DNA nor… 
2004
2004
Preclinical pharmacokinetics and antitumor activity of imexon
SummaryImexon is an aziridine compound originally studied for immune-enhancing effects on lymphocytes. The drug was well… 
2002
2002
Molecular and cellular characterization of imexon-resistant RPMI8226/I myeloma cells.
Imexon is an aziridine-containing iminopyrrolidone with selective growth-inhibitory potency for multiple myeloma. Our previous… 
2002
2002
Imexon activates an intrinsic apoptosis pathway in RPMI8226 myeloma cells
Imexon is a new antitumor agent with high activity in multiple myeloma. This drug induces apoptosis, oxidative stress and… 
1993
1993
Suppression of human lymphoma development in the severe combined immune-deficient mouse by imexon therapy.
Severe combined immune-deficient (SCID) mice accept human cell xenografts. SCID mice inoculated intraperitoneally with human… 
1992
1992
Antiproliferative and antitumor activity of the 2-cyanoaziridine compound imexon on tumor cell lines and fresh tumor cells in vitro.
BACKGROUND Imexon, a 2-cyanoaziridine, is therapeutic and reverses lymphadenopathy and splenomegaly in the LP-BM5 murine… 
1992
1992
Treatment of the murine, retrovirus-induced lymphoproliferative immunodeficiency disease (LP-BM5) in C57BL/10 mice with the immunomodulator Imexon.
Imexon (4-imino-1, 3-diazabicyclo-(3.1.0)-hexan-2-one) a cyanoaziridine compound was studied in the treatment of the murine… 
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