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Idazoxan

Known as: Idazoxan [Chemical/Ingredient] 
A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity.
National Institutes of Health

Related topics

Related topics

14 relations

Narrower (5)

2-methoxyidazoxan6,7-dichloroidazoxanIdazoxan HydrochlorideRX-781094

Broader (2)

Adrenergic alpha-2 Receptor AntagonistsDioxanes
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

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2001
2001
The involvement of α2-adrenoceptors in the anticonvulsive effect of swim stress in mice
Abstract.Rationale: Various studies have shown that stressful manipulations in rats and mice lower the convulsant potency of GABA… 
2001
2001
Involvement of imidazoline receptors in the baroreflex effects of rilmenidine in conscious rabbits
Objective It has been suggested that imidazoline receptors rather than α2-adrenoceptors are involved in the sympathoinhibitory… 
1999
1999
A search for presynaptic imidazoline receptors at rabbit and rat noradrenergic neurones in the absence of α2-autoinhibition
Presynaptic, release-inhibiting imidazoline receptors have hitherto been detected mainly under conditions of ongoing α2… 
1996
1996
Intrathecal Clonidine and Tizanidine in Conscious Dogs: Comparison of Analgesic and Hemodynamic Effects
Intrathecal delivery of alpha2-adrenergic agonists produces an analgesic effect. However, hemodynamic side effects limit their… 
1993
1993
Sympathoinhibitory Action of Rilmenidine in Conscious Sinoaortically Denervated Rats
Summary: The responses of mean arterial pressure (MAP), heart rate (HR), and renal sympathetic nerve activity (RSNA) to… 
1989
1989
Pharmacologic characterization of the receptor mediating the hypnotic action of dexmedetomidine.
The anesthetic-reducing property of medetomidine far exceeds that seen with other alpha 2-adrenergic agonists (e.g., clonidine… 
1987
1987
Possible role of alpha-2-noradrenergic receptors in modulation of sexual behavior in female guinea pigs.
These studies examine whether alpha 1-noradrenergic receptor stimulation alone is sufficient to facilitate lordosis behavior in… 
1986
1986
Alpha-adrenoreceptor reagents. 4. Resolution of some potent selective prejunctional alpha 2-adrenoreceptor antagonists.
The resolution of three 2-substituted derivatives of idazoxan is described. The enantiomers show large separations in activity in… 
1986
1986
Postsynaptic alpha-adrenoceptor characterization and Ca2+ channel antagonist and activator actions in rat tail arteries from normotensive and hypertensive animals.
Postsynaptic alpha-adrenoceptors in the rat tail artery have been examined by determining the pA2 values for antagonists against… 
1986
1986
Studies on alpha 2-adrenoceptors in rabbits with perinephritis hypertension.
Increased responses to intravenous injections of the full alpha 2-adrenoceptor agonists, alpha-methyl noradrenaline and…