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ITM2C protein, human

Known as: BRICHOS domain containing 2C protein, human, integral membrane protein 2C, human, BRI3 protein, human (BRICHOS domain containing) 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Membrane Proteins

Papers overview

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2020
2020
Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro
Molecular chaperones play important roles in preventing protein misfolding and its potentially harmful consequences… 
2020
2020
Recombinant BRICHOS chaperone domains delivered to mouse brain parenchyma by focused ultrasound and microbubbles are internalized by hippocampal and cortical neurons
2020
2020
Recombinant Bri3 BRICHOS domain is a molecular chaperone with effect against amyloid formation and non-fibrillar protein aggregation
Molecular chaperones assist proteins in achieving a functional structure and prevent them from misfolding into aggregates… 
2018
2018
The Bri2 and Bri3 BRICHOS Domains Interact Differently with Aβ42 and Alzheimer Amyloid Plaques
Alzheimer’s disease (AD) is the most common form of dementia and there is no successful treatment available. Evidence suggests… 
2018
2018
Of spiders, bugs, and men : Structural and functional studies of proteins involved in assembly
Protein assembly enables complex machineries while being economical with genetic information. However, protein assembly also… 
Highly Cited
2017
Highly Cited
2017
Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state
Protein misfolding and aggregation is increasingly being recognized as a cause of disease. In Alzheimer’s disease the amyloid… 
2017
2017
BRICHOS – an anti-amyloid chaperone: evaluation of blood-brain barrier permeability of Bri2 BRICHOS
Aggregation of the amyloid–b peptide (Ab) into toxic oligomers and amyloid fibrils is linked to the development of Alzheimer’s… 
2016
2016
Dementia-related Bri2 BRICHOS is a versatile molecular chaperone that efficiently inhibits Aβ42 toxicity in Drosophila.
Formation of fibrils of the amyloid-β peptide (Aβ) is suggested to play a central role in neurodegeneration in Alzheimer's… 
2016
2016
BRICHOS interactions with amyloid proteins and implications for Alzheimer disease
To date, about 30 diseases, in which amyloid fibrils form extracellular deposits, have been identified in humans. It is not known… 
2015
2015
Islet amyloid polypeptide (IAPP) in Type 2 diabetes and Alzheimer disease
The misfolding and aggregation of the beta cell hormone islet amyloid polypeptide (IAPP) into amyloid fibrils is the main… 
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