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Arrest of -Amyloid Fibril Formation by a Pentapeptide Ligand (*)
- L. Tjernberg, J. Näslund, C. Nordstedt
- Biology, ChemistryThe Journal of Biological Chemistry
- 12 April 1996
It is shown that peptides incorporating a short Aβ fragment (KLVFF; Aβ) can bind full-length Aβ and prevent its assembly into amyloid fibrils and suggested that residues Aβ serve as a binding sequence during Aβ polymerization and fibril formation.
Self-assembly of spider silk proteins is controlled by a pH-sensitive relay
It is discovered that incorporation of the amino-terminal domain of major ampullate spidroin 1 from the dragline of the nursery web spider Euprosthenops australis into mini-spidroins enables immediate, charge-dependent self-assembly at pH values around 6.3, but delays aggregation above pH 7.
Role of C-peptide in human physiology.
- J. Wahren, K. Ekberg, H. Jörnvall
- Biology, MedicineAmerican journal of physiology. Endocrinology and…
- 1 May 2000
The possibility exists that C-peptide replacement, together with insulin administration, may prevent the development or retard the progression of long-term complications in type 1 diabetes.
Molecular structures and interactions of pulmonary surfactant components.
The dominating functional property of pulmonary surfactant is to reduce the surface tension at the alveolar air/liquid interface, and thereby prevent the lungs from collapsing at the end of…
Molecular basis for amyloid fibril formation and stability.
- O. S. Makin, E. Atkins, P. Sikorski, J. Johansson, L. Serpell
- Materials ScienceProceedings of the National Academy of Sciences…
- 11 January 2005
The molecular structure of the amyloid fibril has remained elusive because of the difficulty of growing well diffracting crystals, but by using a sequence-designed polypeptide, these crystals diffract to high resolution by electron and x-ray diffraction, enabling the structure to be determined.
The proteins of the surfactant system.
In babies with respiratory distress syndrome, the clinical response to treatment with surfactant containing SP-B and SP-C is much faster than in babies treated with protein-free synthetic surfactants.
Uropathogenic Escherichia coli Modulates Immune Responses and Its Curli Fimbriae Interact with the Antimicrobial Peptide LL-37
The data demonstrate that biofilm components are involved in the pathogenesis of urinary tract infections by E. coli and can be a target of local immune defense mechanisms.
Spider silk proteins: recent advances in recombinant production, structure–function relationships and biomedical applications
Miniaturized spidroins designed by linking the terminal domains with a limited number of repetitive segments recapitulate the properties of native spidROins to a surprisingly large extent, provided that they are produced and isolated in a manner that retains water solubility until fibre formation is triggered.
Structure and properties of surfactant protein C.
- J. Johansson
- Biology, ChemistryBiochimica et biophysica acta
- 19 November 1998
N-terminal nonrepetitive domain common to dragline, flagelliform, and cylindriform spider silk proteins.
A close comparison with published sequences revealed the presence of N-terminal signal peptides followed by an approximately 130-residue nonrepetitive domain that is concluded to contain five alpha-helices and is a conserved constituent of hitherto analyzed dragline, flagelliform, and cylindriform spider silk proteins.