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ITGAM protein, human

Known as: MAC1 Alpha, CD11b, Integrin Alpha-M 
Integrin alpha-M (1152 aa, ~127 kDa) is encoded by the human ITGAM gene. This protein is involved in both leukocyte adhesion and the phagocytosis of… 
National Institutes of Health

Related topics

Related topics

14 relations
CD11B Expressing Cell CountCell AdhesionClusters of differentiationGlycoproteins

Broader (1)

CD11b Antigens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The NF-kB regulates the SHP-1 expression in monocytes in congestive heart failure.
It has been shown that functional recovery of patients with acute congestive heart failure (ACHF) after treatment with… 
2017
2017
Systemic lupus erythematosus: Defective CD11b raises IFN levels in SLE
Genetic variants of ITGAM that produce integrin αM (also known as CD11b) with reduced activity are associated with increased… 
2012
2012
Effects of cryopreservation with polyethylene glycol on the expression of CD11b and CD62L on the surface of polymorphonuclear leukocytes.
In experimental and clinical studies, expression of surface adhesion molecules such as ß2-integrine (CD11b) and L-selectin (CD62L… 
Review
2002
Review
2002
Molecular nature of antigens implicated in immune neutropenias
Granulocyte (neutrophil) antibodies can cause autoimmune neutropenia, drug-induced neutropenia, immune neutropenia after bone… 
2002
2002
Regulation of adhesion of AML14.3D10 cells by surface clustering of β2‐integrin caused by ERK‐independent activation of cPLA2
We examined the role of cell surface clustering of β2‐integrin caused by protein kinase C (PKC)‐activated‐cPLA2 in adhesion of… 
Highly Cited
1999
Highly Cited
1999
‘Outside‐in’ signalling mechanisms underlying CD11b/CD18‐mediated NADPH oxidase activation in human adherent blood eosinophils
Incubation of human eosinophils in BSA‐coated tissue culture plates resulted in time‐dependent adhesion and attendant activation… 
1998
1998
[The effect of PMN adhesion mediated by CD11b/CD18 on the increasing permeability of microvascular endothelial monolayer after severe burn injury].
OBJECTIVE To detect the effect of burn-activated PMN adhesion and its adhesion molecule CD11b/CD18 on microvascular endothelial… 
Highly Cited
1992
Highly Cited
1992
Leucocyte adhesion protein deficiency in Irish setter dogs.
Highly Cited
1989
Highly Cited
1989
Regulation of expression of the CD11b and CD18 subunits of the neutrophil adherence receptor during human myeloid differentiation.
The receptor on human myeloid cells that mediates cellular adherence consists of a heterodimer complex (designated CD11b/CD18… 
1989
1989
cDNA sequence for the alpha M subunit of the human neutrophil adherence receptor indicates homology to integrin alpha subunits.
The receptor on human neutrophils (polymorphonuclear leukocytes) that mediates cellular adherence consists of two noncovalently… 
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