Pharmacology of the eosinophil.
- M. Giembycz, M. Lindsay
- MedicinePharmacological Reviews
- 1 June 1999
Rapid Changes in MicroRNA-146a Expression Negatively Regulate the IL-1β-Induced Inflammatory Response in Human Lung Alveolar Epithelial Cells1
- M. Perry, S. Moschos, A. Williams, Neil J Shepherd, H. Larner-Svensson, M. Lindsay
- BiologyJournal of Immunology
- 15 April 2008
It is demonstrated that changes in the expression of miRNAs can also regulate acute inflammatory responses in human lung alveolar epithelial cells and that rapid increase in miRNA-146a expression provides a novel mechanism for the negative regulation of severe inflammation during the innate immune response.
microRNAs and the immune response
- E. Tsitsiou, M. Lindsay
- BiologyCurrent opinion in pharmacology (Print)
- 1 August 2009
Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids
- S. Moschos, A. Williams, M. Perry, M. Birrell, M. Belvisi, M. Lindsay
- Biology, MedicineBMC Genomics
- 17 July 2007
It is shown that the LPS-induced innate immune response is associated with widespread, rapid and transient increases in miRNA expression in the mouse lung and it is speculated that these changes might be involved in the regulation of the inflammatory response.
Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes
- Nicholas E. IIott, J. Heward, M. Lindsay
- BiologyNature Communications
- 9 June 2014
Early reports indicate that long non-coding RNAs (lncRNAs) are novel regulators of biological responses. However, their role in the human innate immune response, which provides the initial defence…
Characterisation of cell‐penetrating peptide‐mediated peptide delivery
- Simon W. Jones, R. Christison, M. Lindsay
- Biology, ChemistryBritish Journal of Pharmacology
- 1 August 2005
It is shown by FACS analysis that unconjugated antennapedia, TAT, transportan and polyarginine demonstrate similar kinetic uptake profiles, being maximal at 1–3 h and independent of cell type (HeLa, A549 and CHO cell lines).
Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity.
- S. Moschos, Simon W. Jones, M. Lindsay
- Biology, ChemistryBioconjugate chemistry
- 21 August 2007
It is suggested that conjugation to cholesterol may extend but not increase siRNA-mediated p38 MAP kinase mRNA knockdown in the lung, and the use of CPP may be limited due to as yet uncharacterized effects upon gene expression and a potential for immune activation.
MicroRNA Expression Profiling in Mild Asthmatic Human Airways and Effect of Corticosteroid Therapy
- A. Williams, H. Larner-Svensson, M. Lindsay
- Biology, MedicinePLoS ONE
- 12 June 2009
Changes in miRNA expression do not appear to be involved in the development of a mild asthmatic phenotype or in the anti-inflammatory action of the corticosteroid budesonide.
Role of miRNA-146a in the regulation of the innate immune response and cancer.
- A. Williams, M. Perry, S. Moschos, H. Larner-Svensson, M. Lindsay
- BiologyBiochemical Society Transactions
- 1 December 2008
The evidence for a role of miR-146a in innate immunity and cancer is reviewed and whether changes in miR -146a might link these two biological responses are assessed.
The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL‐1β‐dependent PGE2 release via mechanistically distinct processes
- R. Newton, Lisa Cambridge, L. Hart, David A. Stevens, M. Lindsay, P. J. Barnes
- Biology, ChemistryBritish Journal of Pharmacology
- 1 July 2000
It is concluded that the MEK1, MEK2 and p38 MAP kinase inhibitors, PD098059, UO126 and SB203580, are highly potent in respect of inflammatory PG release and act via mechanistically distinct processes, which may have anti‐inflammatory benefits.
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