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INPP5B gene

Known as: INPP5B, INOSITOL POLYPHOSPHATE-5-PHOSPHATASE, 75-KD, inositol polyphosphate-5-phosphatase B 
National Institutes of Health

Related topics

Related topics

1 relation
INPP5D gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Identification of Inhibitors of Inositol 5-Phosphatases through Multiple Screening Strategies
Phosphoinositides are low abundance membrane phospholipids that have key roles in signaling, membrane trafficking, and… 
2013
2013
Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe
Inositol phosphatases are important regulators of cell signaling, polarity, and vesicular trafficking. Mutations in OCRL, an… 
Highly Cited
2012
Highly Cited
2012
Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling
Sealing of phagosomes is accompanied by the disappearance of phosphatidylinositol (4,5)‐bisphosphate (PtdIns(4,5)P2) from their… 
Highly Cited
2012
Highly Cited
2012
Yersinia entry into host cells requires Rab5-dependent dephosphorylation of PI(4,5)P₂ and membrane scission.
2010
2010
Multivariate analysis of male reproductive function in Inpp5b-/- mice reveals heterogeneity in defects in fertility, sperm-egg membrane interaction and proteolytic cleavage of sperm ADAMs.
Past work indicated that sperm from mice deficient in the inositol polyphosphate 5-phosphatase Inpp5b have reduced ability to… 
2010
2010
Species-specific difference in expression and splice-site choice in Inpp5b, an inositol polyphosphate 5-phosphatase paralogous to the enzyme deficient in Lowe Syndrome
The oculocerebrorenal syndrome of Lowe (OCRL; MIM #309000) is an X-linked human disorder characterized by congenital cataracts… 
2010
2010
X-inactivation analysis of embryonic lethality in Ocrlwt/−;Inpp5b−/− mice
Mutations in the human OCRL gene, which encodes a phosphatidylinositol(4,5)bisphosphate 5-phosphatase, result in the X-linked… 
Highly Cited
2009
Highly Cited
2009
A PH domain within OCRL bridges clathrin‐mediated membrane trafficking to phosphoinositide metabolism
OCRL, whose mutations are responsible for Lowe syndrome and Dent disease, and INPP5B are two similar proteins comprising a… 
Highly Cited
2007
Highly Cited
2007
Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway
The inositol polyphosphate 5-phosphatase INPP5B is closely related to the Lowe syndrome protein OCRL1, sharing a similar… 
Highly Cited
1998
Highly Cited
1998
Functional overlap between murine Inpp5b and Ocrl1 may explain why deficiency of the murine ortholog for OCRL1 does not cause Lowe syndrome in mice.
The oculocerebrorenal syndrome of Lowe (OCRL) is an X-linked human genetic disorder characterized by mental retardation… 
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