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INO 1001

Known as: INO-1001, INO1001 
A isoindolinone derivative and potent inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) with chemosensitization and… 
National Institutes of Health

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3 relations

Broader (1)

Indoles
NCIt Antineoplastic Agent TerminologyPARP1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
PARP inhibitors blaze a trail in difficult-to-treat cancers
volume 27 number 9 september 2009 nature biotechnology Big players have been carving out a niche in the small but thriving field… 
2008
2008
Poly (ADP) ribose synthetase inhibition in alveolar macrophages undergoing hypoxia and reoxygenation.
2006
2006
Immunomodulatory effects of poly(ADP-ribose) polymerase inhibition contribute to improved cardiac function and survival during acute cardiac rejection.
2006
2006
Poly(ADP-ribose) polymerase inhibition reverses vascular dysfunction after gamma-irradiation.
2006
2006
Evaluation of tolerability, safety, and pharmacokinetics of INO-1001 plus temozolomide (TMZ) in patients with unresectable stage III/IV melanoma.
12015 Background: TMZ, an orally bioavailable cytotoxic agent with the same active metabolite as DTIC, is a commonly used for… 
2006
2006
Poly(ADP-ribose) polymerase inhibition combined with irradiation: a dual treatment concept to prevent neointimal hyperplasia after endarterectomy.
2006
2006
Genentech raises stakes on PARP inhibitors
The recent, eye-catching entry of Genentech, based in S. San Francisco, California, into the poly (ADP-Ribose) polymerase (PARP… 
2006
2006
In vitro effect of the potent poly(ADP-ribose) polymerase (PARP) inhibitor INO-1001 alone and in combination with aspirin, eptifibatide, tirofiban, enoxaparin or alteplase on haemostatic parameters.
2005
2005
Poly (ADP) ribose polymerase inhibition improves rat cardiac allograft survival.
2005
2005
Poly(Adenosine diphosphate-ribose) polymerase inhibition preserves erectile function in rats after cavernous nerve injury.
PURPOSE We investigated the involvement of poly(adenosine diphosphate-ribose) (PAR) polymerase (PARP) activation in the… 
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