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INO 1001

Known as: INO-1001, INO1001 
A isoindolinone derivative and potent inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) with chemosensitization and… 
National Institutes of Health

Related topics

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3 relations

Broader (1)

Indoles
NCIt Antineoplastic Agent TerminologyPARP1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Poly(ADP-Ribose) Polymerase 1 Inhibition Improves Coronary Arteriole Function in Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) is associated with microvascular dysfunction. We hypothesized that increased poly(ADP-ribose… 
2008
2008
Poly (ADP) ribose synthetase inhibition in alveolar macrophages undergoing hypoxia and reoxygenation.
2008
2008
Ischemic and inflammatory lung impairment by extracorporeal circulation: effect of PARP-inhibition by INO1001.
2006
2006
Immunomodulatory effects of poly(ADP-ribose) polymerase inhibition contribute to improved cardiac function and survival during acute cardiac rejection.
2006
2006
Poly(ADP-ribose) polymerase inhibition reverses vascular dysfunction after gamma-irradiation.
2006
2006
Evaluation of tolerability, safety, and pharmacokinetics of INO-1001 plus temozolomide (TMZ) in patients with unresectable stage III/IV melanoma.
12015 Background: TMZ, an orally bioavailable cytotoxic agent with the same active metabolite as DTIC, is a commonly used for… 
2005
2005
Poly (ADP) ribose polymerase inhibition improves rat cardiac allograft survival.
2005
2005
Beneficial effects of PJ34 and INO-1001, two novel water-soluble poly(ADP-ribose) polymerase inhibitors, on the consequences of traumatic brain injury in rat
2005
2005
Poly(Adenosine diphosphate-ribose) polymerase inhibition preserves erectile function in rats after cavernous nerve injury.
PURPOSE We investigated the involvement of poly(adenosine diphosphate-ribose) (PAR) polymerase (PARP) activation in the… 
2004
2004
Poly (ADP) ribose synthetase inhibition reduces obliterative airway disease in rat tracheal allografts.
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