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Successful cell division requires the precise and timely coordination of chromosomal, cytoskeletal and membrane trafficking… Expand The centromere is a complex structure, the components and assembly pathway of which remain inadequately defined. Here, we… Expand Aurora family serine/threonine kinases control mitotic progression, and their deregulation is implicated in tumorigenesis. Aurora… Expand The function of the Aurora B kinase at centromeres and the central spindle is crucial for chromosome segregation and cytokinesis… Expand The dramatic condensation of chromosomes that occurs during mitosis is widely thought to be largely controlled by a protein… Expand How the events of mitosis are coordinated is not well understood. Intriguing mitotic regulators include the chromosomal passenger… Expand We have performed a biochemical and double-stranded RNA-mediated interference (RNAi) analysis of the role of two chromosomal… Expand Chromosomal passengers are proteins that move from centromeres to the spindle midzone during mitosis. Recent experiments show… Expand BACKGROUND
Survivin is a mammalian protein that carries a motif typical of the inhibitor of apoptosis (IAP)proteins, first… Expand BACKGROUND
In animal cells, cytokinesis begins shortly after the sister chromatids move to the spindle poles. The inner… Expand