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Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
TLDR
A novel protease resembling ICE (prICE) that is active in a cell-free system that reproduces the morphological and biochemical events of apoptosis in the extracts including morphological changes, cleavage of PARP and production of an oligonucleosomal ladder. Expand
Mammalian caspases: structure, activation, substrates, and functions during apoptosis.
TLDR
This work has shown that apoptotic cell death is a genetically programmed, morphologically distinct form of cell death that can be triggered by a variety of physiological and pathological stimuli, and that proteases play critical roles in initiation and execution of this process. Expand
Chromosomal passengers: conducting cell division
TLDR
Research into the chromosomal passenger complex, which comprises Aurora-B protein kinase, the inner centromere protein INCENP, survivin and borealin, is providing insights into its functions, which range from chromosome–microtubule interactions to sister chromatid cohesion to cytokinesis. Expand
The cellular geography of Aurora kinases
TLDR
Aurora kinases regulate the structure and function of the cytoskeleton and chromosomes and the interactions between these two at the kinetochore during mitosis and regulate signalling by the spindle-assembly checkpoint pathway and cytokinesis. Expand
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis
TLDR
This work has shown that Aurora B is one of the most intensively studied kinases and in conjunction with inner centromere protein, borealin and survivin it forms the chromosomal passenger complex (CPC), which regulates key mitotic events. Expand
Essential Roles of Drosophila Inner Centromere Protein (Incenp) and Aurora B in Histone H3 Phosphorylation, Metaphase Chromosome Alignment, Kinetochore Disjunction, and Chromosome Segregation
TLDR
It is revealed that INCENP is required for aurora B kinase function and confirmed that the chromosomal passengers have essential roles in mitosis. Expand
Chromosomal passengers and the (aurora) ABCs of mitosis.
TLDR
The chromosomal passenger complex functions throughout mitosis in chromosome condensation and segregation, and at the end of mitosis, in the completion of cytokinesis. Expand
The dynamic kinetochore-microtubule interface
TLDR
The kinetochore is a control module that both powers and regulates chromosome segregation in mitosis and meiosis, and recent work has revealed that many kinetchore components are highly dynamic and that some cycle between Kinetochores and spindle poles along microtubules. Expand
Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.
TLDR
Borealin is described and results implicate the chromosomal passenger holocomplex in the maintenance of spindle integrity and suggest that histone H3 serine10 phosphorylation is performed by an Aurora B-INCENP subcomplex. Expand
INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow
TLDR
It is reported that INCenP is stockpiled in Xenopus eggs in a complex with Xenopus AIRK2 (XAIRK2), and that INCENP and AIRK1 kinase bind one another in vitro, and that this association was found to be evolutionarily conserved. Expand
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