Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
- Y. Lazebnik, S. Kaufmann, S. Desnoyers, G. Poirier, W. Earnshaw
- BiologyNature
- 22 September 1994
A novel protease resembling ICE (prICE) that is active in a cell-free system that reproduces the morphological and biochemical events of apoptosis in the extracts including morphological changes, cleavage of PARP and production of an oligonucleosomal ladder.
Mammalian caspases: structure, activation, substrates, and functions during apoptosis.
- W. Earnshaw, L. Martins, S. Kaufmann
- BiologyAnnual Review of Biochemistry
- 1999
This work has shown that apoptotic cell death is a genetically programmed, morphologically distinct form of cell death that can be triggered by a variety of physiological and pathological stimuli, and that proteases play critical roles in initiation and execution of this process.
Chromosomal passengers: conducting cell division
- S. Ruchaud, M. Carmena, W. Earnshaw
- BiologyNature reviews. Molecular cell biology
- 1 October 2007
Research into the chromosomal passenger complex, which comprises Aurora-B protein kinase, the inner centromere protein INCENP, survivin and borealin, is providing insights into its functions, which range from chromosome–microtubule interactions to sister chromatid cohesion to cytokinesis.
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis
- M. Carmena, Michael S Wheelock, H. Funabiki, W. Earnshaw
- BiologyNature reviews. Molecular cell biology
- 1 December 2012
This work has shown that Aurora B is one of the most intensively studied kinases and in conjunction with inner centromere protein, borealin and survivin it forms the chromosomal passenger complex (CPC), which regulates key mitotic events.
The cellular geography of Aurora kinases
- M. Carmena, W. Earnshaw
- BiologyNature reviews. Molecular cell biology
- 1 November 2003
Aurora kinases regulate the structure and function of the cytoskeleton and chromosomes and the interactions between these two at the kinetochore during mitosis and regulate signalling by the spindle-assembly checkpoint pathway and cytokinesis.
Essential Roles of Drosophila Inner Centromere Protein (Incenp) and Aurora B in Histone H3 Phosphorylation, Metaphase Chromosome Alignment, Kinetochore Disjunction, and Chromosome Segregation
- R. Adams, H. Maiato, W. Earnshaw, M. Carmena
- BiologyJournal of Cell Biology
- 14 May 2001
It is revealed that INCENP is required for aurora B kinase function and confirmed that the chromosomal passengers have essential roles in mitosis.
Chromosomal passengers and the (aurora) ABCs of mitosis.
- R. Adams, M. Carmena, W. Earnshaw
- BiologyTrends in Cell Biology
- 1 February 2001
Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.
- R. Gassmann, Ana Carvalho, W. Earnshaw
- BiologyJournal of Cell Biology
- 19 July 2004
Borealin is described and results implicate the chromosomal passenger holocomplex in the maintenance of spindle integrity and suggest that histone H3 serine10 phosphorylation is performed by an Aurora B-INCENP subcomplex.
The dynamic kinetochore-microtubule interface
- H. Maiato, J. DeLuca, E. Salmon, W. Earnshaw
- BiologyJournal of Cell Science
- 1 November 2004
The kinetochore is a control module that both powers and regulates chromosome segregation in mitosis and meiosis, and recent work has revealed that many kinetchore components are highly dynamic and that some cycle between Kinetochores and spindle poles along microtubules.
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