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The Chromosomal Passenger Complex Is Required for Chromatin-Induced Microtubule Stabilization and Spindle Assembly
The identification of Dasra A and Dasra B are reported, two new components of the vertebrate chromosomal passenger complex containing Incenp, Survivin, and the kinase Aurora B, and it is demonstrated that this complex is required for chromatin-induced microtubule stabilization and spindle formation. Expand
Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation.
The results show that MCAK regulation of cytoplasmic and spindle-associated microtubules can be differentiated by Aurora B-dependent phosphorylation, and they further demonstrate that this regulation is required for bipolar meiotic spindle assembly. Expand
The Kinesin-8 Kif18A Dampens Microtubule Plus-End Dynamics
The findings suggest that kinesin-8 family members have developed biochemically distinct activities throughout evolution and have implications for how Kif18A affects kinetochore-microtubule plus-end dynamics during mitosis in animal cells. Expand
Comparison of three directly coupled HPLC MS/MS strategies for identification of proteins from complex mixtures: single-dimension LC-MS/MS, 2-phase MudPIT, and 3-phase MudPIT
Abstract One of the most effective methods for the direct identification of proteins from complex mixtures without first having to resolve them by polyacrylamide gel electrophoresis is to separateExpand
A tethering mechanism controls the processivity and kinetochore-microtubule plus-end enrichment of the kinesin-8 Kif18A.
The heightened processivity of Kif18A, conferred by its tail domain, thus promotes concentration of K if18A at K-MT plus ends, where it suppresses their dynamics to control chromosome movements. Expand
Kinesin-12 Differentially Affects Spindle Assembly Depending on Its Microtubule Substrate
It is demonstrated that Kif15 acts on parallel MT arrays and clarifies its role under both normal and pathological conditions, and it is found that K if15 bound to kinetochore fibers antagonizes centrosome separation while Kif 15 bound to nonkinetochores MTs mediates centrosomes separation. Expand
Regulating the onset of mitosis.
  • R. Ohi, K. Gould
  • Biology, Medicine
  • Current opinion in cell biology
  • 1 April 1999
Evidence gathered in the past two years has underscored the importance of positioning MPF and its regulators in the proper place at the proper time to ensure orderly progression through the G2/M transition. Expand
XRHAMM Functions in Ran-Dependent Microtubule Nucleation and Pole Formation during Anastral Spindle Assembly
The Xenopus ortholog of human RHAMM is identified as a microtubule-associated protein that plays a role in focusing spindle poles and is essential for efficient micro Tubule nucleation during spindle assembly without centrosomes. Expand
Microtubule-depolymerizing kinesins.
The microtubule (MT) cytoskeleton supports a broad range of cellular functions, from providing tracks for intracellular transport, to supporting movement of cilia and flagella, to segregatingExpand
An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin.
By immunoelectron microscopy, it is found that ICIS is present on the surface of inner centromeres, placing it in an ideal location to depolymerize microtubules associated laterally with inner centromres and provide a mechanism that prevents kinetochore-microtubule attachment errors. Expand