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IMPDH1 gene

Known as: IMPDH1, IMP (Inosine Monophosphate) Dehydrogenase 1 Gene, INOSINE-5-PRIME-MONOPHOSPHATE DEHYDROGENASE, TYPE I 
This gene plays a role in the regulation of cell growth.
National Institutes of Health

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IMPDH1 wt Allele
IMPDH1, humanLEBER CONGENITAL AMAUROSIS 11Nucleotide MetabolismOxidation-Reduction

Papers overview

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Highly Cited
2012
Highly Cited
2012
Different Characteristics and Nucleotide Binding Properties of Inosine Monophosphate Dehydrogenase (IMPDH) Isoforms
We recently reported that Inosine Monophosphate Dehydrogenase (IMPDH), a rate-limiting enzyme in de novo guanine nucleotide… 
Highly Cited
2011
Highly Cited
2011
Mycophenolate, clinical pharmacokinetics, formulations, and methods for assessing drug exposure.
Review
2009
Review
2009
The TeGenero Incident and the Duff Report Conclusions: A Series of Unfortunate Events or an Avoidable Event?
The administration of the first dose of a novel pharmaceutical compound to humans is the culmination of many years of efforts by… 
Highly Cited
2008
Highly Cited
2008
IMPDH1 Gene Polymorphisms and Association With Acute Rejection in Renal Transplant Patients
Inosine 5′‐monophosphate dehydrogenase 1 (IMPDH1) catalyzes the rate‐limiting step of the de novo pathway for purine synthesis… 
Highly Cited
2008
Highly Cited
2008
Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10).
Mutations within the inosine 5'-monophosphate dehydrogenase 1 (IMPDH1) gene cause the RP10 form of autosomal dominant retinitis… 
Highly Cited
2007
Highly Cited
2007
IMPDH1 promoter mutations in a patient exhibiting azathioprine resistance
Around 9% of inflammatory bowel disease (IBD) patients are resistant to azathioprine. We hypothesized that these patients may… 
Highly Cited
2006
Highly Cited
2006
Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital amaurosis.
PURPOSE The purpose of this study was to determine the frequency and spectrum of inosine monophosphate dehydrogenase type I… 
Highly Cited
2006
Highly Cited
2006
Why do mutations in the ubiquitously expressed housekeeping gene IMPDH1 cause retina-specific photoreceptor degeneration?
PURPOSE The purpose of this study was to investigate retinal inosine monophosphate dehydrogenase 1 (IMPDH1) transcripts and… 
Highly Cited
2004
Highly Cited
2004
On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa.
Retinitis pigmentosa (RP), the hereditary degenerative disease of the photoreceptor neurons of the retina, probably represents… 
Highly Cited
1987
Highly Cited
1987
Inosine monophosphate dehydrogenase and myeloid cell maturation.
In previous studies of purine ribonucleotide metabolism in the human myeloid leukemia cell line HL-60, we observed that there is… 
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