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IL13-PE38QQR

Known as: IL 13-PE38QQR, IL-13 Toxin, Interleukin-13 PE38QQR Immunotoxin 
A recombinant chimeric protein with potent antitumor activity. Cintredekin besudotox is composed of interleukin-13 (IL13), a pleiotropic… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

ExotoxinsInterleukin-13

Papers overview

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Review
2011
Review
2011
A comprehensive outlook on intracerebral therapy of malignant gliomas.
Highly Cited
2010
Highly Cited
2010
Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma.
Convection-enhanced delivery (CED) of cintredekin besudotox (CB) was compared with Gliadel wafers (GW) in adult patients with… 
Highly Cited
2010
Highly Cited
2010
Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics
Restricting the cytotoxicity of anticancer agents by targeting receptors exclusively expressed on tumor cells is critical when… 
Highly Cited
2007
Highly Cited
2007
Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group.
PURPOSE Glioblastoma multiforme (GBM) is a devastating brain tumor with a median survival of 6 months after recurrence… 
Highly Cited
2007
Highly Cited
2007
INTRACEREBRAL INFUSATE DISTRIBUTION BY CONVECTION‐ENHANCED DELIVERY IN HUMANS WITH MALIGNANT GLIOMAS: DESCRIPTIVE EFFECTS OF TARGET ANATOMY AND CATHETER POSITIONING
OBJECTIVE Convection-enhanced delivery (CED) holds tremendous potential for drug delivery to the brain. However, little is known… 
Highly Cited
2007
Highly Cited
2007
CONVECTION‐ENHANCED DELIVERY OF CINTREDEKIN BESUDOTOX (INTERLEUKIN‐13‐PE38QQR) FOLLOWED BY RADIATION THERAPY WITH AND WITHOUT TEMOZOLOMIDE IN NEWLY DIAGNOSED MALIGNANT GLIOMAS: PHASE 1 STUDY OF FINAL…
OBJECTIVECintredekin besudotox (CB), a recombinant cytotoxin consisting of interleukin-13 and truncated Pseudomonas exotoxin… 
Highly Cited
2007
Highly Cited
2007
Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions.
Convection-enhanced delivery (CED) is a novel drug delivery technique that uses positive infusion pressure to deliver therapeutic… 
Review
2007
Review
2007
Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin.
OBJECTIVE Convection-enhanced delivery is a promising approach to intracerebral drug delivery in which a fluid pressure gradient… 
Review
2003
Review
2003
Convection enhanced delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: presentation of interim findings from ongoing phase 1 studies.
  • S. Kunwar
  • Acta neurochirurgica. Supplement
  • 2003
  • Corpus ID: 36036134
IL13PE38QQR is a recombinant toxin composed of the enzymatically-active portion of Pseudomonas Exotoxin A conjugated with human… 
Highly Cited
2002
Highly Cited
2002
Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma.
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