Skip to search formSkip to main contentSkip to account menu

IL13-PE38QQR

Known as: IL 13-PE38QQR, IL-13 Toxin, Interleukin-13 PE38QQR Immunotoxin 
A recombinant chimeric protein with potent antitumor activity. Cintredekin besudotox is composed of interleukin-13 (IL13), a pleiotropic… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

ExotoxinsInterleukin-13

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Therapeutic Efficacy of Cintredekin Besudotox (IL13-PE38QQR) in Murine Lung Fibrosis Is Unaffected by Immunity to Pseudomonas aeruginosa Exotoxin A
Background We have previously explored a therapeutic strategy for specifically targeting the profibrotic activity of IL-13 during… 
Review
2008
Review
2008
Cintredekin besudotox in treatment of malignant glioma.
BACKGROUND Interleukin-13 (IL-13) receptors are overexpressed in glioblastoma multiforme (GBM). The presence of IL-13 binding… 
Review
2008
Review
2008
Current available therapies and future directions in the treatment of malignant gliomas
The prognosis of patients diagnosed with malignant glioma (MG) remains poor. However, recent advances in neuro-oncology allowing… 
Review
2006
Review
2006
The IL-4 and IL-13 pseudomonas exotoxins: new hope for brain tumor therapy.
Targeting cell surface receptors with cytotoxins or immunotoxins provides a unique opportunity for brain tumor therapy. The… 
Highly Cited
2005
Highly Cited
2005
Neuroradiographic changes following convection-enhanced delivery of the recombinant cytotoxin interleukin 13-PE38QQR for recurrent malignant glioma.
OBJECT Convection-enhanced delivery (CED) is a novel method for delivering therapeutic agents to infiltrative brain tumor cells… 
2001
2001
Gene transfer of interleukin 13 receptor α2 chain dramatically enhances the antitumor effect of IL-13 receptor–targeted cytotoxin in human prostate cancer xenografts
IL-13Rα2 chain, the primary interleukin-13 (IL-13) binding protein, plays an important role in IL-13 binding and internalization… 
Highly Cited
2001
Highly Cited
2001
Identification of Distinct Roles for a Dileucine and a Tyrosine Internalization Motif in the Interleukin (IL)-13 Binding Component IL-13 Receptor α2 Chain*
Interleukin (IL)-13 receptor α2 (IL-13Rα2) chain is an essential binding component for IL-13-mediated ligand binding. Recently… 
Highly Cited
2000
Highly Cited
2000
Interleukin-13 fusion cytotoxin as a potent targeted agent for AIDS-Kaposi's sarcoma xenograft.
Clinically advanced and rapidly progressive AIDS-associated Kaposi sarcoma (AIDS-KS) tumors require an aggressive tumor-directed… 
2000
2000
Sensitization of cancer cells to interleukin 13-pseudomonas exotoxin-induced cell death by gene transfer of interleukin 13 receptor alpha chain.
We have demonstrated that primary interleukin 13 (IL-13) binding protein IL-13 receptor (IL-13R) alpha chain plays an important… 
1995
1995
Recombinant F(ab') C242-Pseudomonas exotoxin, but not the whole antibody-based immunotoxin, causes regression of a human colorectal tumor xenograft.
We have previously made a Mr 195,000 immunotoxin (IT) composed of mAb C242 coupled to Pseudomonas exotoxin A. This IT inhibited… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)