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IL13-PE38QQR

Known as: IL 13-PE38QQR, IL-13 Toxin, Interleukin-13 PE38QQR Immunotoxin 
A recombinant chimeric protein with potent antitumor activity. Cintredekin besudotox is composed of interleukin-13 (IL13), a pleiotropic… 
National Institutes of Health

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2 relations

Broader (2)

ExotoxinsInterleukin-13

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Therapeutic Efficacy of Cintredekin Besudotox (IL13-PE38QQR) in Murine Lung Fibrosis Is Unaffected by Immunity to Pseudomonas aeruginosa Exotoxin A
Background We have previously explored a therapeutic strategy for specifically targeting the profibrotic activity of IL-13 during… 
Review
2008
Review
2008
Cintredekin besudotox in treatment of malignant glioma.
BACKGROUND Interleukin-13 (IL-13) receptors are overexpressed in glioblastoma multiforme (GBM). The presence of IL-13 binding… 
Review
2008
Review
2008
Current available therapies and future directions in the treatment of malignant gliomas
The prognosis of patients diagnosed with malignant glioma (MG) remains poor. However, recent advances in neuro-oncology allowing… 
Highly Cited
2005
Highly Cited
2005
Neuroradiographic changes following convection-enhanced delivery of the recombinant cytotoxin interleukin 13-PE38QQR for recurrent malignant glioma.
OBJECT Convection-enhanced delivery (CED) is a novel method for delivering therapeutic agents to infiltrative brain tumor cells… 
Review
2005
Review
2005
Technology evaluation: cintredekin besudotox, NeoPharm/Nippon.
NeoPharm Inc, under license from the National Institutes of Health and the FDA, and in collaboration with the Japanese licensee… 
2004
2004
Nitric Oxide Accelerates Interleukin-13 Cytotoxin-Mediated Regression in Head and Neck Cancer Animal Model
Receptors for interleukin-13 (IL-13R) are overexpressed on several types of solid cancers including gliobastoma, renal cell… 
2001
2001
Gene transfer of interleukin 13 receptor α2 chain dramatically enhances the antitumor effect of IL-13 receptor–targeted cytotoxin in human prostate cancer xenografts
IL-13Rα2 chain, the primary interleukin-13 (IL-13) binding protein, plays an important role in IL-13 binding and internalization… 
Highly Cited
2000
Highly Cited
2000
Interleukin-13 fusion cytotoxin as a potent targeted agent for AIDS-Kaposi's sarcoma xenograft.
Clinically advanced and rapidly progressive AIDS-associated Kaposi sarcoma (AIDS-KS) tumors require an aggressive tumor-directed… 
2000
2000
Sensitization of cancer cells to interleukin 13-pseudomonas exotoxin-induced cell death by gene transfer of interleukin 13 receptor alpha chain.
We have demonstrated that primary interleukin 13 (IL-13) binding protein IL-13 receptor (IL-13R) alpha chain plays an important… 
1995
1995
Recombinant F(ab') C242-Pseudomonas exotoxin, but not the whole antibody-based immunotoxin, causes regression of a human colorectal tumor xenograft.
We have previously made a Mr 195,000 immunotoxin (IT) composed of mAb C242 coupled to Pseudomonas exotoxin A. This IT inhibited… 
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