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IL13-PE38QQR
Known as:
IL 13-PE38QQR
, IL-13 Toxin
, Interleukin-13 PE38QQR Immunotoxin
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A recombinant chimeric protein with potent antitumor activity. Cintredekin besudotox is composed of interleukin-13 (IL13), a pleiotropic…
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National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Exotoxins
Interleukin-13
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
A comprehensive outlook on intracerebral therapy of malignant gliomas.
C. Buonerba
,
G. Di Lorenzo
,
+7 authors
J. Sampson
Critical reviews in oncology/hematology
2011
Corpus ID: 10344486
Highly Cited
2010
Highly Cited
2010
Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma.
S. Kunwar
,
Susan M. Chang
,
+14 authors
S. Tatter
Neuro-oncology
2010
Corpus ID: 11348339
Convection-enhanced delivery (CED) of cintredekin besudotox (CB) was compared with Gliadel wafers (GW) in adult patients with…
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Highly Cited
2010
Highly Cited
2010
Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics
M. Candolfi
,
W. Xiong
,
+15 authors
M. Castro
Proceedings of the National Academy of Sciences
2010
Corpus ID: 30293458
Restricting the cytotoxicity of anticancer agents by targeting receptors exclusively expressed on tumor cells is critical when…
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Highly Cited
2007
Highly Cited
2007
Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group.
S. Kunwar
,
M. Prados
,
+11 authors
R. Puri
Journal of clinical oncology : official journal…
2007
Corpus ID: 42362808
PURPOSE Glioblastoma multiforme (GBM) is a devastating brain tumor with a median survival of 6 months after recurrence…
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Highly Cited
2007
Highly Cited
2007
INTRACEREBRAL INFUSATE DISTRIBUTION BY CONVECTION‐ENHANCED DELIVERY IN HUMANS WITH MALIGNANT GLIOMAS: DESCRIPTIVE EFFECTS OF TARGET ANATOMY AND CATHETER POSITIONING
J. Sampson
,
M. Brady
,
+8 authors
C. Pedain
Neurosurgery
2007
Corpus ID: 8878839
OBJECTIVE Convection-enhanced delivery (CED) holds tremendous potential for drug delivery to the brain. However, little is known…
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Highly Cited
2007
Highly Cited
2007
CONVECTION‐ENHANCED DELIVERY OF CINTREDEKIN BESUDOTOX (INTERLEUKIN‐13‐PE38QQR) FOLLOWED BY RADIATION THERAPY WITH AND WITHOUT TEMOZOLOMIDE IN NEWLY DIAGNOSED MALIGNANT GLIOMAS: PHASE 1 STUDY OF FINAL…
M. Vogelbaum
,
J. Sampson
,
+10 authors
R. Puri
Neurosurgery
2007
Corpus ID: 21282078
OBJECTIVECintredekin besudotox (CB), a recombinant cytotoxin consisting of interleukin-13 and truncated Pseudomonas exotoxin…
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Highly Cited
2007
Highly Cited
2007
Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions.
J. Sampson
,
R. Raghavan
,
+13 authors
C. Pedain
Neuro-oncology
2007
Corpus ID: 7546023
Convection-enhanced delivery (CED) is a novel drug delivery technique that uses positive infusion pressure to deliver therapeutic…
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Review
2007
Review
2007
Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin.
J. Sampson
,
R. Raghavan
,
+7 authors
C. Pedain
AJR. American journal of roentgenology
2007
Corpus ID: 45312146
OBJECTIVE Convection-enhanced delivery is a promising approach to intracerebral drug delivery in which a fluid pressure gradient…
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Review
2003
Review
2003
Convection enhanced delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: presentation of interim findings from ongoing phase 1 studies.
S. Kunwar
Acta neurochirurgica. Supplement
2003
Corpus ID: 36036134
IL13PE38QQR is a recombinant toxin composed of the enzymatically-active portion of Pseudomonas Exotoxin A conjugated with human…
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Highly Cited
2002
Highly Cited
2002
Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma.
K. Blease
,
J. M. Schuh
,
+6 authors
C. Hogaboam
The American journal of pathology
2002
Corpus ID: 23981742
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