IFI16 gene

Known as: IFNGIP1, IFI16, Interferon, Gamma-Inducible Protein 16 Gene 
This gene plays a role in transcriptional regulation, cell differentiation and immune response-mediated programmed cell death.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
The progressive depletion of quiescent “bystander” CD4 T cells, which are nonpermissive to HIV infection, is a principal driver… (More)
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Highly Cited
2013
Highly Cited
2013
Replication of lentiviruses generates different DNA forms, including RNA:DNA hybrids, ssDNA, and dsDNA. Nucleic acids stimulate… (More)
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Highly Cited
2013
Highly Cited
2013
Inflammasomes are multiprotein complexes that recognize pathogens and pathogen- or danger-associated molecular patterns. They… (More)
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Highly Cited
2013
Highly Cited
2013
Nuclear sensing of viral DNA has emerged as an essential step in innate immune responses against herpesviruses. Here, we provide… (More)
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Highly Cited
2012
Highly Cited
2012
Human interferon (IFN)-inducible IFI16 protein, an innate immune sensor of intracellular DNA, modulates various cell functions… (More)
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Highly Cited
2012
Highly Cited
2012
Innate sensing of microbial components is well documented to occur at many cellular sites, including at the cell surface, in the… (More)
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Highly Cited
2012
Highly Cited
2012
Detection of pathogenic nucleic acids is essential for mammalian innate immunity. IFN-inducible protein IFI16 has emerged as a… (More)
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Highly Cited
2012
Highly Cited
2012
Recognition of DNA by the innate immune system is central to antiviral and antibacterial defenses, as well as an important… (More)
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Highly Cited
2011
Highly Cited
2011
Inflammasomes are cytoplasmic sensors of foreign molecules, including pathogens, and function to induce caspase-1 activation and… (More)
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Highly Cited
2010
Highly Cited
2010
The detection of intracellular microbial DNA is critical to appropriate innate immune responses; however, knowledge of how such… (More)
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